| pubmed-article:9184224 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C1556138 | lld:lifeskim |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C1621443 | lld:lifeskim |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C1622028 | lld:lifeskim |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C1332667 | lld:lifeskim |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C0180459 | lld:lifeskim |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C1705370 | lld:lifeskim |
| pubmed-article:9184224 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9184224 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9184224 | pubmed:dateCreated | 1997-7-7 | lld:pubmed |
| pubmed-article:9184224 | pubmed:abstractText | Upon activation, the apoptosis-inducing cell membrane receptor CD95 (APO-1/Fas) recruits a set of intracellular signaling proteins (CAP1-4) into a death-inducing signaling complex (DISC). In the DISC, CAP1 and CAP2 represent FADD/MORT1. CAP4 was identified recently as an ICE-like protease, FLICE, with two death effector domains (DED). Here we show that FLICE binds to FADD through its N-terminal DED. This is an obligatory step in CD95 signaling detected in the DISC of all CD95-sensitive cells tested. Upon prolonged triggering of CD95 with agonistic antibodies all cytosolic FLICE gets proteolytically activated. Physiological FLICE cleavage requires association with the DISC and occurs by a two-step mechanism. Initial cleavage generates a p43 and a p12 fragment further processed to a p10 fragment. Subsequent cleavage of the receptor-bound p43 results in formation of the prodomain p26 and the release of the active site-containing fragment p18. Activation of FLICE is blocked by the peptide inhibitors zVAD-fmk, zDEVD-fmk and zIETD-fmk, but not by crmA or Ac-YVAD-CHO. Taken together, our data indicate that FLICE is the first in a cascade of ICE-like proteases activated by CD95 and that this activation requires a functional CD95 DISC. | lld:pubmed |
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| pubmed-article:9184224 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9184224 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9184224 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9184224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9184224 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9184224 | pubmed:month | May | lld:pubmed |
| pubmed-article:9184224 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9184224 | pubmed:author | pubmed-author:KrammerP HPH | lld:pubmed |
| pubmed-article:9184224 | pubmed:author | pubmed-author:MannMM | lld:pubmed |
| pubmed-article:9184224 | pubmed:author | pubmed-author:ShevchenkoAA | lld:pubmed |
| pubmed-article:9184224 | pubmed:author | pubmed-author:PeterM EME | lld:pubmed |
| pubmed-article:9184224 | pubmed:author | pubmed-author:MedemaJ PJP | lld:pubmed |
| pubmed-article:9184224 | pubmed:author | pubmed-author:KischkelF CFC | lld:pubmed |
| pubmed-article:9184224 | pubmed:author | pubmed-author:ScaffidiCC | lld:pubmed |
| pubmed-article:9184224 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9184224 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9184224 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:9184224 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9184224 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9184224 | pubmed:pagination | 2794-804 | lld:pubmed |
| pubmed-article:9184224 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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