| pubmed-article:9173989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0051318 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C0205812 | lld:lifeskim |
| pubmed-article:9173989 | lifeskim:mentions | umls-concept:C2347816 | lld:lifeskim |
| pubmed-article:9173989 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9173989 | pubmed:dateCreated | 1997-8-11 | lld:pubmed |
| pubmed-article:9173989 | pubmed:abstractText | Kainate-activated Co2+ uptake, a histochemical method that identifies cells bearing Ca2+-permeable AMPA/kainate receptors, labels approximately 15% of murine cortical neurones in cell culture. While exposure times exceeding several hours were needed for AMPA or kainate to destroy most cultured cortical neurones, the subpopulation exhibiting kainate-activated Co2+ uptake was selectively destroyed after AMPA or kainate exposures of only 10-60 min. No selective loss was seen after exposure to NMDA. Kainate toxicity on Co2+ uptake-positive neurones was dependent on extracellular Ca2+ concentration, and associated with an increase in intracellular free Ca2+ even in the absence of extracellular Na+. These results suggest that a distinct subpopulation of cortical neurones expresses AMPA/kainate receptors linked to Ca2+-permeable channels, and that this characteristic conveys enhanced vulnerability to kainate-induced, Ca2+-mediated, damage. | lld:pubmed |
| pubmed-article:9173989 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9173989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9173989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9173989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9173989 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9173989 | pubmed:issn | 0969-9961 | lld:pubmed |
| pubmed-article:9173989 | pubmed:author | pubmed-author:WeissJ HJH | lld:pubmed |
| pubmed-article:9173989 | pubmed:author | pubmed-author:CohnN HNH | lld:pubmed |
| pubmed-article:9173989 | pubmed:author | pubmed-author:GoldbergM PMP | lld:pubmed |
| pubmed-article:9173989 | pubmed:author | pubmed-author:CanzonieroL... | lld:pubmed |
| pubmed-article:9173989 | pubmed:author | pubmed-author:SensiS LSL | lld:pubmed |
| pubmed-article:9173989 | pubmed:author | pubmed-author:TuretskyD MDM | lld:pubmed |
| pubmed-article:9173989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9173989 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:9173989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9173989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9173989 | pubmed:pagination | 101-10 | lld:pubmed |
| pubmed-article:9173989 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:meshHeading | pubmed-meshheading:9173989-... | lld:pubmed |
| pubmed-article:9173989 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:9173989 | pubmed:articleTitle | Cortical neurones exhibiting kainate-activated Co2+ uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity. | lld:pubmed |
| pubmed-article:9173989 | pubmed:affiliation | Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri, 63110, USA. | lld:pubmed |
| pubmed-article:9173989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9173989 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9173989 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9173989 | lld:pubmed |
