| pubmed-article:9169989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9169989 | lifeskim:mentions | umls-concept:C0280100 | lld:lifeskim |
| pubmed-article:9169989 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:9169989 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9169989 | pubmed:dateCreated | 1997-7-10 | lld:pubmed |
| pubmed-article:9169989 | pubmed:abstractText | A co-polymer of O-methyl polyethylene(glycol)-O'-succinate (MPEGs, m.w. 5100) and poly-l-lysine (PL, median m.w. 32700, degree of polymerization 256) has been synthesized by covalent grafting. The resultant MPEGs-PL (30% modification degree of epsilon-amino groups) had a hydrodynamic diameter corresponding to a 690 kD protein. Free amino groups (180/mol of the co-polymer) were used for conjugation of diethylene pentaacetic or succinic acid residues to MPEGs-PL. The potential of the resultant compound as a carrier of therapeutic and diagnostic drugs was studied using a rodent carcinoma models. The co-polymer had a blood pool half-life of 36h in adenocarcinoma-bearing rats. Radioactively labeled preparations were resistant to trans-chelation with apotransferrin and stable in blood for 24 h. The co-polymer accumulated in solid tumors at the level of 1.5-2% injected dose/g of tumor in 24 h. At that time, 34-40% of the accumulated polymer was associated with tumor cell fraction. The co-polymer non-covalently associated with cis-diamminedichloroplatinum(II), showed a cytostatic effect against mouse F9 carcinoma, and induced a reversal in tumor growth after intravenous administration. | lld:pubmed |
| pubmed-article:9169989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9169989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9169989 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9169989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9169989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9169989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9169989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9169989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9169989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9169989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9169989 | pubmed:issn | 1061-186X | lld:pubmed |
| pubmed-article:9169989 | pubmed:author | pubmed-author:MartinCC | lld:pubmed |
| pubmed-article:9169989 | pubmed:author | pubmed-author:WrightS CSC | lld:pubmed |
| pubmed-article:9169989 | pubmed:author | pubmed-author:WeisslederRR | lld:pubmed |
| pubmed-article:9169989 | pubmed:author | pubmed-author:BogdanovaAA | lld:pubmed |
| pubmed-article:9169989 | pubmed:author | pubmed-author:BogdanovAAJr | lld:pubmed |
| pubmed-article:9169989 | pubmed:author | pubmed-author:MarecosE MEM | lld:pubmed |
| pubmed-article:9169989 | pubmed:author | pubmed-author:PetherickPP | lld:pubmed |
| pubmed-article:9169989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9169989 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:9169989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9169989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9169989 | pubmed:pagination | 321-30 | lld:pubmed |
| pubmed-article:9169989 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:meshHeading | pubmed-meshheading:9169989-... | lld:pubmed |
| pubmed-article:9169989 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9169989 | pubmed:articleTitle | A long-circulating co-polymer in "passive targeting" to solid tumors. | lld:pubmed |
| pubmed-article:9169989 | pubmed:affiliation | Department of Radiology, Massachusetts General Hospital, Boston 02129, USA. abogdanov@helix.mgh.harvard.edu | lld:pubmed |
| pubmed-article:9169989 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9169989 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9169989 | lld:pubmed |
