| pubmed-article:9168613 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9168613 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:9168613 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:9168613 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:9168613 | lifeskim:mentions | umls-concept:C0968147 | lld:lifeskim |
| pubmed-article:9168613 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:9168613 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:9168613 | pubmed:dateCreated | 1997-7-21 | lld:pubmed |
| pubmed-article:9168613 | pubmed:abstractText | This work reports the role of both superoxide dismutases-CuZnSOD (encoded by SOD1) and MnSOD (encoded by SOD2)-in the build-up of tolerance to ethanol during growth of Saccharomyces cerevisiae from exponential to post-diauxic phase. Both enzyme activities increase from the exponential phase to the diauxic shift and from the diauxic shift to the post-diauxic phase. The levels of mRNA-SOD1 and mRNA-SOD2 increase from the exponential phase to the diauxic shift; however, during the post-diauxic phase mRNA-SOD1 levels decrease while mRNA-SOD2 levels remain unchanged. These data indicate the existence of two regulatory mechanisms involved in the induction of SOD activity during growth: synthesis de novo of the proteins (until the diauxic shift), and post-transcriptional or post-translational regulation (during the post-diauxic phase). Ethanol does not alter the activities of either enzyme in cells from the diauxic shift or post-diauxic-phases, although the respective mRNA levels decrease in post-diauxic-phase cells treated with ethanol (14% or 20%). Results of experiments with sod1 and sod2 mutants show that MnSOD, but not CuZnSOD, is essential for ethanol tolerance of diauxic-shift and post-diauxic-phase cells. Evidence that ethanol toxicity is correlated with the production of reactive oxygen species in the mitochondria is obtained from results with respiration-deficient mutants. In these cells, the induction of superoxide dismutase activity by ethanol is low; also, the respiratory deficiency restores the capacity of sod2 cells to acquire ethanol tolerance. | lld:pubmed |
| pubmed-article:9168613 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9168613 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9168613 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9168613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9168613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9168613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9168613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9168613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9168613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9168613 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9168613 | pubmed:month | May | lld:pubmed |
| pubmed-article:9168613 | pubmed:issn | 1350-0872 | lld:pubmed |
| pubmed-article:9168613 | pubmed:author | pubmed-author:CostaVV | lld:pubmed |
| pubmed-article:9168613 | pubmed:author | pubmed-author:ReisEE | lld:pubmed |
| pubmed-article:9168613 | pubmed:author | pubmed-author:AmorimM AMA | lld:pubmed |
| pubmed-article:9168613 | pubmed:author | pubmed-author:Moradas-Ferre... | lld:pubmed |
| pubmed-article:9168613 | pubmed:author | pubmed-author:QuintanilhaAA | lld:pubmed |
| pubmed-article:9168613 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9168613 | pubmed:volume | 143 ( Pt 5) | lld:pubmed |
| pubmed-article:9168613 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9168613 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9168613 | pubmed:pagination | 1649-56 | lld:pubmed |
| pubmed-article:9168613 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:meshHeading | pubmed-meshheading:9168613-... | lld:pubmed |
| pubmed-article:9168613 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9168613 | pubmed:articleTitle | Mitochondrial superoxide dismutase is essential for ethanol tolerance of Saccharomyces cerevisiae in the post-diauxic phase. | lld:pubmed |
| pubmed-article:9168613 | pubmed:affiliation | Departamento de Biologia Molecular, Universidade do Porto, Portugal. | lld:pubmed |
| pubmed-article:9168613 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9168613 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9168613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9168613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9168613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9168613 | lld:pubmed |
