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pubmed-article:9166475pubmed:abstractTextMembers of a family carrying a constitutional balanced translocation [t(3;8) (p14;q24)] have a high risk of developing multiple, bilateral clear-cell renal carcinomas. Two genetic mechanisms of carcinogenesis for this malignancy have been proposed: (1) disruption of a gene at the translocation breakpoint and (2) mutation of the von Hippel-Lindau tumor-suppressor gene at 3p25. This study further evaluates the role of the von Hippel-Lindau gene in the etiology and pathogenesis of t(3;8)-associated renal carcinomas.lld:pubmed
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pubmed-article:9166475pubmed:articleTitleMechanism of tumorigenesis of renal carcinomas associated with the constitutional chromosome 3;8 translocation.lld:pubmed
pubmed-article:9166475pubmed:affiliationBiological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, USA.lld:pubmed
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