| pubmed-article:9164586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C0379900 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:9164586 | lifeskim:mentions | umls-concept:C0254672 | lld:lifeskim |
| pubmed-article:9164586 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9164586 | pubmed:dateCreated | 1997-7-30 | lld:pubmed |
| pubmed-article:9164586 | pubmed:abstractText | The present experiments examined the ability of the novel 5-HT1A receptor antagonist to block responses mediated by postsynaptic and presynaptic 5-HT1A receptors in vivo. Pretreatment with p-MPPI reduced or blocked the effect of the 5-HT1A receptor agonist 8-OH-DPAT on two responses mediated by postsynaptic 5-HT1A receptors, reduction of body temperature and the 5-HT behavioral syndrome. Administration of p-MPPI alone did not alter body temperature or produce symptoms of the 5-HT syndrome. Pretreatment with p-MPPI also blocked the ability of 8-OH-DPAT to reduce extracellular 5-HT in the striatum, a response mediated by presynaptic 5-HT1A receptors in the dorsal raphe nucleus, but did not alter striatal 5-HT when administered alone. These results indicate that p-MPPI is an effective 5-HT1A receptor antagonist in vivo with no intrinsic activity. p-MPPI may prove to be a useful pharmacological tool for studying 5-HT1A receptors and their involvement in anxiety and affective disorders. | lld:pubmed |
| pubmed-article:9164586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9164586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9164586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9164586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9164586 | pubmed:issn | 0091-3057 | lld:pubmed |
| pubmed-article:9164586 | pubmed:author | pubmed-author:SinghAA | lld:pubmed |
| pubmed-article:9164586 | pubmed:author | pubmed-author:AllenA RAR | lld:pubmed |
| pubmed-article:9164586 | pubmed:author | pubmed-author:MARSP HPH | lld:pubmed |
| pubmed-article:9164586 | pubmed:author | pubmed-author:KunsM DMD | lld:pubmed |
| pubmed-article:9164586 | pubmed:author | pubmed-author:LuckiII | lld:pubmed |
| pubmed-article:9164586 | pubmed:author | pubmed-author:ZhuangZ PZP | lld:pubmed |
| pubmed-article:9164586 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9164586 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:9164586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9164586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9164586 | pubmed:pagination | 301-7 | lld:pubmed |
| pubmed-article:9164586 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9164586 | pubmed:meshHeading | pubmed-meshheading:9164586-... | lld:pubmed |
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| pubmed-article:9164586 | pubmed:articleTitle | The 5-HT1A receptor antagonist p-MPPI blocks responses mediated by postsynaptic and presynaptic 5-HT1A receptors. | lld:pubmed |
| pubmed-article:9164586 | pubmed:affiliation | Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-2649, USA. | lld:pubmed |
| pubmed-article:9164586 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9164586 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9164586 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
