| pubmed-article:9151704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9151704 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9151704 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:9151704 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:9151704 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9151704 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:9151704 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9151704 | pubmed:dateCreated | 1997-6-24 | lld:pubmed |
| pubmed-article:9151704 | pubmed:abstractText | Antibody responses against antibodies, such as rheumatoid factors, are found in several immunopathological diseases and may play a role in disease pathogenesis. Experience shows that they are usually difficult to induce experimentally. Antibodies specific for immunoglobulin constant regions (anti-allotypic) or for variable regions (anti-idiotypic) have been investigated in animal models; the latter have even been postulated to regulate antibody and T cell responses via network-like interactions. Why and how such anti-antibodies are induced during autoimmune diseases, has remained largely unclear. Because repetitively arranged epitopes in a paracrystalline structure of a viral envelope cross-link B cell receptors efficiently to induce a prompt T-independent IgM response, this study used immune complexes containing viruses or bacteria to evaluate the role of antigen pattern for induction of anti-antibody responses. We present evidence that antibodies bound to strictly ordered, but not to irregularly arranged, antigens dramatically enhance induction of anti-antibodies, already after a single immunization and without using adjuvants. The results indicate a novel link between anti-antibody responses and infectious agents, and suggest a similar role for repetitive self-antigens such as DNA or collagen involved in chronic immunopathological diseases. | lld:pubmed |
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| pubmed-article:9151704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9151704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9151704 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9151704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9151704 | pubmed:month | May | lld:pubmed |
| pubmed-article:9151704 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:ZinkernagelR... | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:HengartnerHH | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:BucherEE | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:ECKER SRS | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:LangA BAB | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:KalinkeUU | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:Di PadovaF... | lld:pubmed |
| pubmed-article:9151704 | pubmed:author | pubmed-author:BachmannM FMF | lld:pubmed |
| pubmed-article:9151704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9151704 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:9151704 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:9151704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9151704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9151704 | pubmed:pagination | 1785-92 | lld:pubmed |
| pubmed-article:9151704 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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