| pubmed-article:9144491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9144491 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:9144491 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:9144491 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:9144491 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:9144491 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9144491 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:9144491 | lifeskim:mentions | umls-concept:C0439098 | lld:lifeskim |
| pubmed-article:9144491 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9144491 | pubmed:dateCreated | 1997-6-2 | lld:pubmed |
| pubmed-article:9144491 | pubmed:abstractText | Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before Ab class switch recombination. Although the cytokine IL-4 is well known to induce transcription of unrearranged C epsilon and C gamma1 genes, it has been shown recently that CD40 signaling also induces these transcripts in mouse B cells. We report in this study that treatment of mouse M12.4.1 B lymphoma cells with soluble CD40 ligand (CD40L)-CD8alpha fusion protein modestly induces the promoter for germline epsilon transcripts, and that this induction synergizes with IL-4. CD40L induces binding of nuclear factor (NF)-kappaB/Rel proteins to two tandem kappaB sites located immediately 3' to the IL-4-responsive region of the mouse germline epsilon promoter. The epsilon-124/-56 promoter segment containing the IL-4 response region and the two kappaB sites is sufficient to transfer CD40L and IL-4 inducibility to a minimal c-fos promoter when transiently transfected into M12.4.1 cells. Mutation of the two kappaB sites eliminates induction by CD40L or by IL-4, and treatment of M12.4.1 cells with inhibitors of NF-kappaB activation prevents induction of endogenous germline epsilon transcripts in M12.4.1 cells. In addition to the NF-kappaB/Rel complexes induced by CD40L, two nuclear complexes, each which contain both STAT6 and NF-kappaB/Rel proteins, are induced in splenic B cells by a combination of CD40L and IL-4, and bind to the CD40L/IL-4-responsive region of the germline epsilon promoter. The presence of these complexes may explain the synergistic induction of transcription by CD40L and IL-4 mediated through this promoter segment. | lld:pubmed |
| pubmed-article:9144491 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9144491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9144491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9144491 | pubmed:month | May | lld:pubmed |
| pubmed-article:9144491 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9144491 | pubmed:author | pubmed-author:StavnezerJJ | lld:pubmed |
| pubmed-article:9144491 | pubmed:author | pubmed-author:IciekL ALA | lld:pubmed |
| pubmed-article:9144491 | pubmed:author | pubmed-author:DelphinS ASA | lld:pubmed |
| pubmed-article:9144491 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9144491 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9144491 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:9144491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9144491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9144491 | pubmed:pagination | 4769-79 | lld:pubmed |
| pubmed-article:9144491 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9144491 | pubmed:meshHeading | pubmed-meshheading:9144491-... | lld:pubmed |
| pubmed-article:9144491 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9144491 | pubmed:articleTitle | CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction. | lld:pubmed |
| pubmed-article:9144491 | pubmed:affiliation | Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA. | lld:pubmed |
| pubmed-article:9144491 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9144491 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9144491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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