Linked Life Data

9143219

Source:http://linkedlifedata.com/resource/pubmed/id/9143219

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pubmed-article:9143219pubmed:abstractTextWe used transgenic mice expressing a dominant negative mutation of interleukin-1 beta converting enzyme (ICE) (C285G) in a model of transient focal ischemia in order to investigate the role of ICE in ischemic brain damage. Transgenic mutant ICE mice (n = 11) and wild-type littermates (n = 9) were subjected to 3 h of middle cerebral artery occlusion followed by 24 h of reperfusion. Cerebral infarcts and brain swelling were reduced by 44% and 46%, respectively. Neurological deficits were also significantly reduced. Regional CBF, blood pressure, core temperature, and heart rate did not differ between groups when measured for up to 1 h after reperfusion. Increases in immunoreactive IL-1 beta levels, observed in ischemic wild-type brain at 30 min after reperfusion, were 77% lower in the mutant strain, indicating that proIL-1 beta cleavage is inhibited in the mutants. DNA fragmentation was reduced in the mutants 6 and 24 h after reperfusion. Hence, endogenous expression of an ICE inhibitor confers resistance to cerebral ischemia and brain swelling. Our results indicate that downregulation of ICE expression might provide a useful therapeutic target in cerebral ischemia.lld:pubmed
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pubmed-article:9143219pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9143219pubmed:articleTitleAttenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.lld:pubmed
pubmed-article:9143219pubmed:affiliationStroke and Neurovascular Regulation, Neurosurgical Service, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA.lld:pubmed
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pubmed-article:9143219pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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