Linked Life Data

9133675

Source:http://linkedlifedata.com/resource/pubmed/id/9133675

Statements in which the resource exists.
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pubmed-article:9133675pubmed:abstractTextNeutrophils were shown to express the proteinase-activated receptor-2 (PAR-2), a seven transmembrane domain receptor, which is activated by cleavage by trypsin. Granulocytes from 14 donors stained positively for PAR-2 with affinity-purified rabbit antibodies raised against a peptide corresponding to the trypsin cleavage site of human PAR-2. Neutrophil activation in response to a receptor activating peptide (RAP) varied between donors. RAP (Ser-Leu-Ile-Gly-Lys-Val-NH2) alone induced an increase in the forward and side light scatter after 5-10 minutes and a small increase in the expression of the activation molecule CD11b. The increased expression of CD11b induced by RAP was markedly enhanced by priming the neutrophils with a low concentration (1 nM) of formyl-Leu-Met-Phe. Trypsin and RAP also induced an increase in intracellular calcium, but there were large variations in the magnitude of responses between donors also in this assay. The effects of RAP in the different assays were specific; acetylated RAP was completely without activity.lld:pubmed
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pubmed-article:9133675pubmed:articleTitleProteinase-activated receptor-2: expression by human neutrophils.lld:pubmed
pubmed-article:9133675pubmed:affiliationDepartment of Oral Pathology, St Bartholomew's and the Royal London School of Medicine and Dentistry, UK.lld:pubmed
pubmed-article:9133675pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9133675pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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