| pubmed-article:9129978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9129978 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:9129978 | lifeskim:mentions | umls-concept:C0042164 | lld:lifeskim |
| pubmed-article:9129978 | lifeskim:mentions | umls-concept:C0019740 | lld:lifeskim |
| pubmed-article:9129978 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:9129978 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:9129978 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9129978 | pubmed:dateCreated | 1997-6-26 | lld:pubmed |
| pubmed-article:9129978 | pubmed:abstractText | The major histocompatibility complex (MHC) gene, HLA-B27 is strongly associated with auto-immune uveitis and spondyloarthropathies in humans. Experimental mouse models of autoimmune uveitis involve systemic immunization with the retinal autoantigen interphotoreceptor retinoid binding protein (IRBP). To assess possible roles of HLA-B27 in autoimmune uveitis, as well as to investigate a possible new animal model of human uveitis, inbred strains of C57BL/6 and C57BL/6 possessing the human HLA-B27 or HLA-A2 transgene were immunized with IRBP emulsified in complete Freund's adjuvant (CFA). Dilated eye examinations were performed to assess the timing and clinical course of any ensuing uveitis. Mice were sacrificed 3 to 4 weeks postinjection and the eyes submitted for histopathologic analysis. CFA alone did not produce any clinical uveitis. Fifty percent of eyes from the background C57BL/6 strain developed uveitis as early as 10 days postinjection. Of the eyes demonstrating uveitis, an average clinical score of 2.5 was present. Pathologically, a moderate scleritis and anterior uveitis was present. Fifty percent of A2 transgenic eyes developed uveitis as early as 14 days postinjection with an average clinical score of 2.0. Pathologically, a mild vitritis was present. Uveitis developed in only 20% of B27 transgenic mice and reached a peak on day 28. The average EAU score in diseased animals was 4.5. A dense retinitis and panuveitis was associated with severe vitritis. We conclude that the presence of the B27 gene is associated with a decreased incidence and slower rate of onset of EAU following immunization with IRBP; however, EAU may be more severe in the HLA-B27 expressing animals who do develop disease. | lld:pubmed |
| pubmed-article:9129978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9129978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9129978 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9129978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9129978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9129978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9129978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9129978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9129978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9129978 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9129978 | pubmed:issn | 0198-8859 | lld:pubmed |
| pubmed-article:9129978 | pubmed:author | pubmed-author:ChamberlainJJ | lld:pubmed |
| pubmed-article:9129978 | pubmed:author | pubmed-author:WiggertBB | lld:pubmed |
| pubmed-article:9129978 | pubmed:author | pubmed-author:InmanR DRD | lld:pubmed |
| pubmed-article:9129978 | pubmed:author | pubmed-author:RootmanD SDS | lld:pubmed |
| pubmed-article:9129978 | pubmed:author | pubmed-author:JayVV | lld:pubmed |
| pubmed-article:9129978 | pubmed:author | pubmed-author:WillbanksG... | lld:pubmed |
| pubmed-article:9129978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9129978 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9129978 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:9129978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9129978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9129978 | pubmed:pagination | 188-94 | lld:pubmed |
| pubmed-article:9129978 | pubmed:dateRevised | 2007-7-27 | lld:pubmed |
| pubmed-article:9129978 | pubmed:meshHeading | pubmed-meshheading:9129978-... | lld:pubmed |
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| pubmed-article:9129978 | pubmed:meshHeading | pubmed-meshheading:9129978-... | lld:pubmed |
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| pubmed-article:9129978 | pubmed:meshHeading | pubmed-meshheading:9129978-... | lld:pubmed |
| pubmed-article:9129978 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9129978 | pubmed:articleTitle | Experimental autoimmune uveitis in HLA-B27 transgenic mice. | lld:pubmed |
| pubmed-article:9129978 | pubmed:affiliation | University of Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:9129978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9129978 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
