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pubmed-article:9123736pubmed:abstractTextThe use of neoadjuvant chemotherapy prior to definitive surgery has been firmly established in other areas of oncology, most notably in the treatment to testis and Wilm's tumors. The use of neoadjuvant androgen deprivation therapy (ADT) in conjunction with radical prostatectomy remains a source of controversy. We have conducted phase II and phase III studies to assess the effects of 3 months of preoperative ADT (goserelin and flutamide) on the pathologic staging and postsurgery prostate-specific antigen (PSA) relapse rate. We also reviewed the data confirming the understaging of clinically localized prostatic cancer and the experimental data providing the conceptual support for ADT.lld:pubmed
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pubmed-article:9123736pubmed:articleTitleThe indications, rationale, and results of neoadjuvant androgen deprivation in the treatment of prostatic cancer: Memorial Sloan-Kettering Cancer Center results.lld:pubmed
pubmed-article:9123736pubmed:affiliationDepartment of Surgery, Pathology, and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.lld:pubmed
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