| pubmed-article:9119977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0128897 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9119977 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9119977 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9119977 | pubmed:dateCreated | 1997-4-24 | lld:pubmed |
| pubmed-article:9119977 | pubmed:abstractText | Increasing evidence indicates a key role of chemoattractant cytokines in the accumulation of leukocytes in the central nervous system (CNS) during the course of inflammatory processes. Monocyte chemoattractant protein (MCP-1/JE), a member of the beta-chemokine (C-C chemokine) family, functions as a potent chemoattractant and activator for monocytes. We have investigated the induction of MCP-1 mRNA using in situ hybridization histochemistry (ISH) and characterized its cellular source by combination of ISH and immunocytochemistry in ischemic rat brains as well as in brains of endotoxin-treated rats. Our results show that 6 h-2 d after middle cerebral artery occlusion (MCAO), MCP-1 mRNA is present in astrocytes surrounding the ischemic tissue (penumbra). At later time points (after 4 d), MCP-1 mRNA is found in macrophages and reactive microglia in the infarcted tissue. Peripheral administration of the bacterial lipopolysaccharide (LPS) induced MCP-1 mRNA throughout the brain in a time-dependent manner (1 h-1 d, peak of expression 6-8 h) and was found in astrocytes. In summary, we have found expression of MCP-1 in (a) astrocytes and to a lesser extent in macrophages/reactive microglia after MCA-occlusion and in (b) astrocytes after peripheral administration of LPS. These findings support that MCP-1 is involved in the CNS response to acute trauma or infection and thus may play a key role in inflammatory processes of the brain. | lld:pubmed |
| pubmed-article:9119977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9119977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9119977 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9119977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9119977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9119977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9119977 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9119977 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:9119977 | pubmed:author | pubmed-author:SautetGG | lld:pubmed |
| pubmed-article:9119977 | pubmed:author | pubmed-author:BoddekeH WHW | lld:pubmed |
| pubmed-article:9119977 | pubmed:author | pubmed-author:ButtiniMM | lld:pubmed |
| pubmed-article:9119977 | pubmed:author | pubmed-author:LimontaSS | lld:pubmed |
| pubmed-article:9119977 | pubmed:author | pubmed-author:GourmalaN GNG | lld:pubmed |
| pubmed-article:9119977 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9119977 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:9119977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9119977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9119977 | pubmed:pagination | 35-44 | lld:pubmed |
| pubmed-article:9119977 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9119977 | pubmed:meshHeading | pubmed-meshheading:9119977-... | lld:pubmed |
| pubmed-article:9119977 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9119977 | pubmed:articleTitle | Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration. | lld:pubmed |
| pubmed-article:9119977 | pubmed:affiliation | Sandoz Pharma Ltd., Preclinical Research, Basel, Switzerland. | lld:pubmed |
| pubmed-article:9119977 | pubmed:publicationType | Journal Article | lld:pubmed |
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