pubmed-article:9114042 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0003315 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0162388 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
pubmed-article:9114042 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
pubmed-article:9114042 | pubmed:issue | 9 | lld:pubmed |
pubmed-article:9114042 | pubmed:dateCreated | 1997-5-27 | lld:pubmed |
pubmed-article:9114042 | pubmed:abstractText | Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such peptide/MHC complexes are a desirable target for novel approaches in immunotherapy because of their highly restricted fine specificity. Recently, phage display was used to isolate an antibody that has T cell receptor-like specificity. It recognizes mouse MHC class I H-2Kk molecules complexed with a H-2Kk-restricted influenza virus-derived hemagglutinin peptide (Ha255-262) but does not bind to class I H-2Kk alone, peptide alone, or H-2Kk complexed with other peptides. We have used this antibody to make a recombinant antibody-toxin fusion protein (immunotoxin) and show herein that it specifically kills antigen-presenting cells in a peptide-dependent manner and with T cell receptor-like specificity. We find a striking correlation between the fine specificity of binding of the antibody and the cytotoxic activity of the recombinant immunotoxin. We also show specific killing of influenza virus-infected target cells. The results suggest that it should be possible to develop novel immunotherapeutic strategies against human cancer by making recombinant antibodies that will recognize cancer-related peptides complexed with MHC class I molecules on the surface of cancer cells and using these to deliver toxins, radioisotopes, or cytotoxic drugs to the cancer cells. | lld:pubmed |
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pubmed-article:9114042 | pubmed:language | eng | lld:pubmed |
pubmed-article:9114042 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9114042 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9114042 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9114042 | pubmed:month | Apr | lld:pubmed |
pubmed-article:9114042 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:9114042 | pubmed:author | pubmed-author:PastanII | lld:pubmed |
pubmed-article:9114042 | pubmed:author | pubmed-author:Di CarloAA | lld:pubmed |
pubmed-article:9114042 | pubmed:author | pubmed-author:EngbergJJ | lld:pubmed |
pubmed-article:9114042 | pubmed:author | pubmed-author:FuggerLL | lld:pubmed |
pubmed-article:9114042 | pubmed:author | pubmed-author:ReiterYY | lld:pubmed |
pubmed-article:9114042 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9114042 | pubmed:day | 29 | lld:pubmed |
pubmed-article:9114042 | pubmed:volume | 94 | lld:pubmed |
pubmed-article:9114042 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9114042 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9114042 | pubmed:pagination | 4631-6 | lld:pubmed |
pubmed-article:9114042 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:9114042 | pubmed:year | 1997 | lld:pubmed |
pubmed-article:9114042 | pubmed:articleTitle | Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity. | lld:pubmed |
pubmed-article:9114042 | pubmed:affiliation | Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, Building 37, Room 4E16, National Institutes of Health, Bethesda, MD 20892-4255, USA. | lld:pubmed |
pubmed-article:9114042 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9114042 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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