| pubmed-article:9113129 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9113129 | lifeskim:mentions | umls-concept:C0011889 | lld:lifeskim |
| pubmed-article:9113129 | lifeskim:mentions | umls-concept:C0028127 | lld:lifeskim |
| pubmed-article:9113129 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:9113129 | lifeskim:mentions | umls-concept:C0012186 | lld:lifeskim |
| pubmed-article:9113129 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9113129 | pubmed:dateCreated | 1997-5-29 | lld:pubmed |
| pubmed-article:9113129 | pubmed:abstractText | The modification of [3H]nitrendipine binding sites in rabbit brain membranes with 2,3-butanedione and diethylpyrocarbonate was investigated. 2,3-Butanedione, an arginine-specific reagent, causes a dose- and time-dependent decrease in the number of [3H]nitrendipine binding sites without altering its dissociation constant. Scatchard analysis of the binding data shows that 50 mM 2,3-butanedione decreases the binding capacity of [3H]nitrendipine from a control value of 71 +/- 6 fmol/mg of protein to 40 +/- 3 fmol/mg of protein. Complete and selective protection against inactivation is provided by nifedipine. No decrease of [3H]nitrendipine binding occurs when membranes are pretreated with selective histidine reagent diethylpyrocarbonate. The results indicate that arginine but not histidine residue in L-type calcium channel domain in critical for [3H]nitrendipine binding. | lld:pubmed |
| pubmed-article:9113129 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9113129 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9113129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9113129 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9113129 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9113129 | pubmed:issn | 0197-0186 | lld:pubmed |
| pubmed-article:9113129 | pubmed:author | pubmed-author:LucacchiniAA | lld:pubmed |
| pubmed-article:9113129 | pubmed:author | pubmed-author:MartinsUU | lld:pubmed |
| pubmed-article:9113129 | pubmed:author | pubmed-author:GiustiLL | lld:pubmed |
| pubmed-article:9113129 | pubmed:author | pubmed-author:CostaBB | lld:pubmed |
| pubmed-article:9113129 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9113129 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:9113129 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9113129 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9113129 | pubmed:pagination | 623-7 | lld:pubmed |
| pubmed-article:9113129 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:meshHeading | pubmed-meshheading:9113129-... | lld:pubmed |
| pubmed-article:9113129 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9113129 | pubmed:articleTitle | 2,3-Butanedione inactivates the [3H]nitrendipine binding sites, whereas diethylpyrocarbonate does not. | lld:pubmed |
| pubmed-article:9113129 | pubmed:affiliation | Istituto Policattedra di Discipline Biologiche, Universita di Pisa, Italy. | lld:pubmed |
| pubmed-article:9113129 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9113129 | pubmed:publicationType | Comparative Study | lld:pubmed |
