| pubmed-article:9099965 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C1704689 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0031001 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0522537 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C1522391 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0025241 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:9099965 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:9099965 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9099965 | pubmed:dateCreated | 1997-5-2 | lld:pubmed |
| pubmed-article:9099965 | pubmed:abstractText | An isolated rat hindlimb perfusion model carrying xenografts of the human melanoma cell line MM96 was used to study the effects of perfusion conditions on melphalan distribution. Krebs-Henseleit buffer and Hartmann's solution containing 4.7% bovine serum albumin (BSA) or 2.8% dextran 40 were used as perfusates. Melphalan concentrations in perfusate, tumour nodules and normal tissues were measured using high-performance liquid chromatography (HPLC). Increasing the perfusion flow rates (from 4 to 8 ml min(-1)) resulted in higher tissue blood flow (determined with 51Cr-labelled microspheres) and melphalan uptake by tumour and normal tissues. The distribution of melphalan within tumour nodules and normal tissues was similar for both Krebs-Henseleit buffer and Hartmann's solution; however, tissue concentrations of melphalan were significantly higher for a perfusate containing 2.8% dextran 40 than for one containing 4.7% BSA. The melphalan concentration in the tumour was one-third of that found in the skin if the perfusate contained 4.7% BSA. In conclusion, this study has shown that a high perfusion flow enhances the delivery of melphalan into implanted tumour nodules and normal tissues, and a perfusate with low melphalan binding (no albumin) is preferred for maximum uptake of drug by the tumour. | lld:pubmed |
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| pubmed-article:9099965 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9099965 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9099965 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9099965 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9099965 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:9099965 | pubmed:author | pubmed-author:RobertsM SMS | lld:pubmed |
| pubmed-article:9099965 | pubmed:author | pubmed-author:ParsonsP GPG | lld:pubmed |
| pubmed-article:9099965 | pubmed:author | pubmed-author:WuZ YZY | lld:pubmed |
| pubmed-article:9099965 | pubmed:author | pubmed-author:SmithersB MBM | lld:pubmed |
| pubmed-article:9099965 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9099965 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:9099965 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9099965 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9099965 | pubmed:pagination | 1160-6 | lld:pubmed |
| pubmed-article:9099965 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9099965 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9099965 | pubmed:articleTitle | The effects of perfusion conditions on melphalan distribution in the isolated perfused rat hindlimb bearing a human melanoma xenograft. | lld:pubmed |
| pubmed-article:9099965 | pubmed:affiliation | Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia. | lld:pubmed |
| pubmed-article:9099965 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9099965 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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