| pubmed-article:9098698 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0439858 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0443177 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0205923 | lld:lifeskim |
| pubmed-article:9098698 | lifeskim:mentions | umls-concept:C0082258 | lld:lifeskim |
| pubmed-article:9098698 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:9098698 | pubmed:dateCreated | 1997-6-16 | lld:pubmed |
| pubmed-article:9098698 | pubmed:abstractText | Diazepam-binding inhibitor has been initially isolated from the rat brain from its ability to compete with benzodiazepines for their receptors. We have recently shown that the octadecaneuropeptide (diazepam-binding inhibitor-(33-50) or ODN) induces an increase in cytosolic free Ca2+ concentration ([Ca2+]i) in astroglial cells. The purpose of the present study was to determine whether central-type benzodiazepine receptors or peripheral-type benzodiazepine receptors are involved in the response of cultured rat astrocytes to ODN. The mixed central-/peripheral-type benzodiazepine receptor ligand flunitrazepam (10(-10) to 10(-6) M), the specific peripheral-type benzodiazepine receptor agonist Ro5-4864 (10(-10) to 10(-6) M) and the peripheral-type benzodiazepine receptor 'antagonist' PK 11195 (10(-9) to 10(-6) M) all induced a dose-dependent increase in [Ca2+]i. At high doses (10(-7) to 10(-5) M), the central-type benzodiazepine receptor agonist clonazepam also mimicked the stimulatory effect of ODN on [Ca2+]i. However, the [Ca2+]i rise induced by ODN was blocked neither by PK 11195 nor by the central-type benzodiazepine receptor antagonist flumazenil (10(-6) M each). Binding of [3H]flunitrazepam to intact astrocytes was displaced by low concentrations of the peripheral-type benzodiazepine receptor ligands flunitrazepam, Ro5 4864 and PK 11195, and by high concentrations of clonazepam. In contrast, ODN did not compete for [3H]flunitrazepam binding in intact cells. These data indicate that the effect of ODN on Ca2+ mobilization in rat astrocytes is mediated by high affinity receptors which are not related to classical benzodiazepine receptors. | lld:pubmed |
| pubmed-article:9098698 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9098698 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9098698 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9098698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9098698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9098698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9098698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9098698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9098698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9098698 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9098698 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9098698 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:9098698 | pubmed:author | pubmed-author:VaudryHH | lld:pubmed |
| pubmed-article:9098698 | pubmed:author | pubmed-author:TononM CMC | lld:pubmed |
| pubmed-article:9098698 | pubmed:author | pubmed-author:PatteCC | lld:pubmed |
| pubmed-article:9098698 | pubmed:author | pubmed-author:GandolfoPP | lld:pubmed |
| pubmed-article:9098698 | pubmed:author | pubmed-author:ThoumasJ LJL | lld:pubmed |
| pubmed-article:9098698 | pubmed:author | pubmed-author:LeprinceJJ | lld:pubmed |
| pubmed-article:9098698 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9098698 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:9098698 | pubmed:volume | 322 | lld:pubmed |
| pubmed-article:9098698 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9098698 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9098698 | pubmed:pagination | 275-81 | lld:pubmed |
| pubmed-article:9098698 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:meshHeading | pubmed-meshheading:9098698-... | lld:pubmed |
| pubmed-article:9098698 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9098698 | pubmed:articleTitle | The stimulatory effect of the octadecaneuropeptide (ODN) on cytosolic Ca2+ in rat astrocytes is not mediated through classical benzodiazepine receptors. | lld:pubmed |
| pubmed-article:9098698 | pubmed:affiliation | European Institute for Peptide Research (IFRMP No. 23), Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France. | lld:pubmed |
| pubmed-article:9098698 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9098698 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9098698 | lld:pubmed |
