| pubmed-article:9095328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0596087 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0950779 | lld:lifeskim |
| pubmed-article:9095328 | lifeskim:mentions | umls-concept:C0950778 | lld:lifeskim |
| pubmed-article:9095328 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9095328 | pubmed:dateCreated | 1997-7-24 | lld:pubmed |
| pubmed-article:9095328 | pubmed:abstractText | Angiogenesis plays a key role in tumor growth, progression and metastasis. The modulation of angiogenesis represents a potentially useful target for novel forms of anticancer therapy. Two such modulators are AGM-1470 (TNP-470, angioinhibin), which is a synthetic analog of the antibiotic fumagallin, and the monoclonal antibody TEC-11 to endoglin. We investigated the mechanisms of action of these modulators on human microvascular and macrovascular endothelial cells and on the transformed endothelial cell line ECV-304 in vitro. The administration of AGM-1470 or TEC-11 resulted in a significant inhibition of cell proliferation in all cell types used; this effect was reversible upon removal of these compounds from the culture medium. Furthermore, biochemical and morphological analyses showed that neither AGM-1470 or TEC-11 induce apoptosis. Both AGM-1470 and TEC-11 inhibited the production of urokinase-type plasminogen activator (u-PA), an enzyme involved in the early steps of neovascularization. Finally, the incubation of endothelial cells with both AGM-1470 and TEC-11 did not produce an additive effect on growth cell inhibition, apoptosis or u-PA production. Since both AGM 1470 and TEC-11 inhibit crucial events such as endothelial cell growth and protease production, our results provide a basis for their therapeutic use as angiostatic molecules in cancer. | lld:pubmed |
| pubmed-article:9095328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9095328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9095328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9095328 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9095328 | pubmed:issn | 0959-4973 | lld:pubmed |
| pubmed-article:9095328 | pubmed:author | pubmed-author:GaspariniGG | lld:pubmed |
| pubmed-article:9095328 | pubmed:author | pubmed-author:DeliaDD | lld:pubmed |
| pubmed-article:9095328 | pubmed:author | pubmed-author:ThorpeP EPE | lld:pubmed |
| pubmed-article:9095328 | pubmed:author | pubmed-author:MaierJ AJA | lld:pubmed |
| pubmed-article:9095328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9095328 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9095328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9095328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9095328 | pubmed:pagination | 238-44 | lld:pubmed |
| pubmed-article:9095328 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9095328 | pubmed:meshHeading | pubmed-meshheading:9095328-... | lld:pubmed |
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| pubmed-article:9095328 | pubmed:meshHeading | pubmed-meshheading:9095328-... | lld:pubmed |
| pubmed-article:9095328 | pubmed:meshHeading | pubmed-meshheading:9095328-... | lld:pubmed |
| pubmed-article:9095328 | pubmed:meshHeading | pubmed-meshheading:9095328-... | lld:pubmed |
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| pubmed-article:9095328 | pubmed:meshHeading | pubmed-meshheading:9095328-... | lld:pubmed |
| pubmed-article:9095328 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9095328 | pubmed:articleTitle | In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11. | lld:pubmed |
| pubmed-article:9095328 | pubmed:affiliation | Department of Biological and Technological Research (DIBIT), San Raffaele Scientific Institute, Milan, Italy. | lld:pubmed |
| pubmed-article:9095328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9095328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9095328 | lld:pubmed |
