| pubmed-article:9092481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0030657 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9092481 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9092481 | pubmed:issue | 5310 | lld:pubmed |
| pubmed-article:9092481 | pubmed:dateCreated | 1997-4-28 | lld:pubmed |
| pubmed-article:9092481 | pubmed:abstractText | The chemokine receptors CXCR4 and CCR5 have recently been shown to act as coreceptors, in concert with CD4, for human immunodeficiency virus-type 1 (HIV-1) infection. RANTES and other chemokines that interact with CCR5 and block infection of peripheral blood mononuclear cell cultures inhibit infection of primary macrophages inefficiently at best. If used to treat HIV-1-infected individuals, these chemokines could fail to influence HIV replication in nonlymphocyte compartments while promoting unwanted inflammatory side effects. A derivative of RANTES that was created by chemical modification of the amino terminus, aminooxypentane (AOP)-RANTES, did not induce chemotaxis and was a subnanomolar antagonist of CCR5 function in monocytes. It potently inhibited infection of diverse cell types (including macrophages and lymphocytes) by nonsyncytium-inducing, macrophage-tropic HIV-1 strains. Thus, activation of cells by chemokines is not a prerequisite for the inhibition of viral uptake and replication. Chemokine receptor antagonists like AOP-RANTES that achieve full receptor occupancy at nanomolar concentrations are strong candidates for the therapy of HIV-1-infected individuals. | lld:pubmed |
| pubmed-article:9092481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9092481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9092481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9092481 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9092481 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:PicardLL | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:OffordR ERE | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:SimmonsGG | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:SchwartzT WTW | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:BuserRR | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:ClaphamP RPR | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:WellsT NTN | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:ProudfootA... | lld:pubmed |
| pubmed-article:9092481 | pubmed:author | pubmed-author:RosenkildeM... | lld:pubmed |
| pubmed-article:9092481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9092481 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:9092481 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:9092481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9092481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9092481 | pubmed:pagination | 276-9 | lld:pubmed |
| pubmed-article:9092481 | pubmed:dateRevised | 2007-11-19 | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:meshHeading | pubmed-meshheading:9092481-... | lld:pubmed |
| pubmed-article:9092481 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9092481 | pubmed:articleTitle | Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. | lld:pubmed |
| pubmed-article:9092481 | pubmed:affiliation | Virology Group, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. | lld:pubmed |
| pubmed-article:9092481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9092481 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9092481 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9092481 | lld:pubmed |
