| pubmed-article:9083328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9083328 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:9083328 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:9083328 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:9083328 | lifeskim:mentions | umls-concept:C0015264 | lld:lifeskim |
| pubmed-article:9083328 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:9083328 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9083328 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:9083328 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9083328 | pubmed:dateCreated | 1997-4-17 | lld:pubmed |
| pubmed-article:9083328 | pubmed:abstractText | As it has been suggested that an autocrine mechanism may control tumour cell growth, in this work cells from a spontaneous murine T lymphocyte leukaemia (LB) expressing the interleukin-2 receptor (IL-2R) (CD25) were evaluated in vitro for IL-2-mediated autocrine growth. Cells grew readily in culture and proliferation was enhanced by the addition of recombinant IL-2 but inhibited by monoclonal antibodies against either IL-2 or IL-2 receptor, in the absence of exogenous IL-2. Cyclosporin A also inhibited LB cell growth. However, when exogenous IL-2 was added together with cyclosporin A, cell proliferation proved similar to controls. Using reverse transcription polymerase chain reaction (PCR), mRNA for IL-2 was found to be present in tumour cells. Our findings support the hypothesis that LB tumour cell proliferation is mediated by an autocrine pathway involving endogenous IL-2 generation, despite the fact that these cells are not dependent on exogenous IL-2 to grow in culture. | lld:pubmed |
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| pubmed-article:9083328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9083328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9083328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9083328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9083328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9083328 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:9083328 | pubmed:author | pubmed-author:HajosS ESE | lld:pubmed |
| pubmed-article:9083328 | pubmed:author | pubmed-author:AlvarezEE | lld:pubmed |
| pubmed-article:9083328 | pubmed:author | pubmed-author:MonginiCC | lld:pubmed |
| pubmed-article:9083328 | pubmed:author | pubmed-author:WaldnerC ICI | lld:pubmed |
| pubmed-article:9083328 | pubmed:author | pubmed-author:Sánchez... | lld:pubmed |
| pubmed-article:9083328 | pubmed:author | pubmed-author:GravisacoM... | lld:pubmed |
| pubmed-article:9083328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9083328 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:9083328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9083328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9083328 | pubmed:pagination | 946-50 | lld:pubmed |
| pubmed-article:9083328 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
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| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:meshHeading | pubmed-meshheading:9083328-... | lld:pubmed |
| pubmed-article:9083328 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9083328 | pubmed:articleTitle | Interleukin 2 exerts autocrine stimulation on murine T-cell leukaemia growth. | lld:pubmed |
| pubmed-article:9083328 | pubmed:affiliation | Cátedra de Immunologia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, IDEHU, Argentina. | lld:pubmed |
| pubmed-article:9083328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9083328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
