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pubmed-article:9082366pubmed:abstractTextDifferentiation of a cutaneous lymphoma from a reactive lymphoid infiltrate is a demanding challenge for the pathologist. In this retrospective study we examined 24 paraffin-embedded tissue samples from lesions diagnosed as lymphomas and 7 control samples of skin affected by benign changes and with pronounced lymphoid infiltrates for clonal rearrangement of the gamma T-cell-receptor. Using PCR technology we demonstrated clonality in 22 cases of lymphoma (92%). Thus, the primer combination used in this study covering the four main groups (I-IV) of the variable region of the gamma T-cell receptor gene allows high sensitivity. No clonality was demonstrable in any of the 7 control cases. This study demonstrates the growing importance of PCR technology for the diagnosis of lymphoma.lld:pubmed
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pubmed-article:9082366pubmed:monthNovlld:pubmed
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pubmed-article:9082366pubmed:authorpubmed-author:SimonMMlld:pubmed
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pubmed-article:9082366pubmed:authorpubmed-author:KingSSlld:pubmed
pubmed-article:9082366pubmed:authorpubmed-author:SanderC ACAlld:pubmed
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pubmed-article:9082366pubmed:volume17lld:pubmed
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pubmed-article:9082366pubmed:pagination446-50lld:pubmed
pubmed-article:9082366pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9082366pubmed:year1996lld:pubmed
pubmed-article:9082366pubmed:articleTitle[Detection of clonality of cutaneous T-cell lymphomas using polymerase chain reaction].lld:pubmed
pubmed-article:9082366pubmed:affiliationDermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.lld:pubmed
pubmed-article:9082366pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9082366pubmed:publicationTypeEnglish Abstractlld:pubmed
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