| pubmed-article:9081617 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9081617 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9081617 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9081617 | lifeskim:mentions | umls-concept:C0026607 | lld:lifeskim |
| pubmed-article:9081617 | lifeskim:mentions | umls-concept:C0205126 | lld:lifeskim |
| pubmed-article:9081617 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:9081617 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:9081617 | lifeskim:mentions | umls-concept:C0449379 | lld:lifeskim |
| pubmed-article:9081617 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9081617 | pubmed:dateCreated | 1997-4-3 | lld:pubmed |
| pubmed-article:9081617 | pubmed:abstractText | The possibility for long-term depression (LTD) of synaptic transmission in layer II/III horizontal connections within motor cortex was investigated using field potentials and intracellular recordings in rat brain slices. The LTD was induced by low-frequency stimulation at 2 Hz for 10 min in sites displaced horizontally by 0.5 mm from the stimulating electrode. Response amplitude measured 25-30 min after 2 Hz stimulation ended was 79% of baseline values (n = 13) at half maximal stimulation and 59% when 2 Hz stimulus intensity was doubled (n = 10). In 13/15 tested cases LTD in horizontal connections was specific to the activated pathway. Intracellular recordings from six neurons confirmed synaptic character of response depression. Horizontal connections in which LTD was induced retained the capability of increasing synaptic strength. Long-term potentiation could be induced in previously depressed pathways by simultaneous theta burst stimulation of two converging horizontal inputs combined with transient local application of GABA(A) receptor antagonist bicuculline methiodide (mean increase: 45 +/- 8% n = 6) or by simultaneous theta burst stimulation of converging horizontal and vertical inputs (mean change: 26 +/- 6%, n = 5). These data demonstrate that activity-dependent mechanisms may regulate bidirectionally the effectiveness of horizontal synaptic coupling between cortical neurons, thus forming a potential mechanism for plasticity of cortical connections and the representation patterns they support. | lld:pubmed |
| pubmed-article:9081617 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9081617 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9081617 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9081617 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9081617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9081617 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9081617 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9081617 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:9081617 | pubmed:author | pubmed-author:HessGG | lld:pubmed |
| pubmed-article:9081617 | pubmed:author | pubmed-author:DonoghueJ PJP | lld:pubmed |
| pubmed-article:9081617 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9081617 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9081617 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9081617 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9081617 | pubmed:pagination | 658-65 | lld:pubmed |
| pubmed-article:9081617 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9081617 | pubmed:meshHeading | pubmed-meshheading:9081617-... | lld:pubmed |
| pubmed-article:9081617 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9081617 | pubmed:articleTitle | Long-term depression of horizontal connections in rat motor cortex. | lld:pubmed |
| pubmed-article:9081617 | pubmed:affiliation | Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Krakow, Poland. | lld:pubmed |
| pubmed-article:9081617 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9081617 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9081617 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9081617 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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