| pubmed-article:9076340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9076340 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:9076340 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:9076340 | lifeskim:mentions | umls-concept:C0202220 | lld:lifeskim |
| pubmed-article:9076340 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9076340 | pubmed:dateCreated | 1997-5-22 | lld:pubmed |
| pubmed-article:9076340 | pubmed:abstractText | Insulin and insulin-like growth factor-1 (IGF-1) are two structurally related hormones which produce similar biological activities such as metabolic and growth promoting actions. Their receptors, insulin and IGF-1 receptors, also share similarities in both structure and functions such as tyrosine-specific protein kinase. We identified insulin receptor substrate-1 (IRS-1) as a common substrate for insulin and IGF-1 receptor tyrosine kinases. We generated IRS-1 knockout mice and showed that IRS-1 plays a physiological role in signal transduction and biological actions of insulin and IGF-1. We also identified pp190 (IRS-2) as an alternative substrate for IRS-1. | lld:pubmed |
| pubmed-article:9076340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9076340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9076340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9076340 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9076340 | pubmed:issn | 0918-8959 | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:YamauchiTT | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:TakahashiYY | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:TobeKK | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:KadowakiTT | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:YazakiYY | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:UekiKK | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:AkanumaYY | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:MomomuraKK | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:KaburagiYY | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:TamemotoHH | lld:pubmed |
| pubmed-article:9076340 | pubmed:author | pubmed-author:Honda-Yamamot... | lld:pubmed |
| pubmed-article:9076340 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9076340 | pubmed:volume | 43 Suppl | lld:pubmed |
| pubmed-article:9076340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9076340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9076340 | pubmed:pagination | S33-41 | lld:pubmed |
| pubmed-article:9076340 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
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| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
| pubmed-article:9076340 | pubmed:meshHeading | pubmed-meshheading:9076340-... | lld:pubmed |
| pubmed-article:9076340 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9076340 | pubmed:articleTitle | Signal transduction mechanism of insulin and insulin-like growth factor-1. | lld:pubmed |
| pubmed-article:9076340 | pubmed:affiliation | Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:9076340 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9076340 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:9076340 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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