| pubmed-article:9075929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9075929 | lifeskim:mentions | umls-concept:C0037224 | lld:lifeskim |
| pubmed-article:9075929 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9075929 | lifeskim:mentions | umls-concept:C1180347 | lld:lifeskim |
| pubmed-article:9075929 | lifeskim:mentions | umls-concept:C0072402 | lld:lifeskim |
| pubmed-article:9075929 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:9075929 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:9075929 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9075929 | pubmed:dateCreated | 1997-4-15 | lld:pubmed |
| pubmed-article:9075929 | pubmed:abstractText | The Nef protein of human and primate lentiviruses is a key factor in HIV/SIV pathogenesis. Here we report that Nef associates with two different kinases, forming a multiprotein complex at the far N-terminus of the viral protein. One of the kinases was identified as Lck, whereas the second protein was found to be a serine kinase that phosphorylated Nef and Lck in vitro and could be discriminated from the serine kinase identified previously. The Nef-associated kinase complex (NAKC) was demonstrated in COS cells, in HIV-infected cells, and in vitro using recombinant Lck and Nef proteins. Deletion of a short amphipathic alpha-helix in the N-terminus, which was found to be conserved in all Nef proteins, inhibited association of the NAKC and significantly reduced virion infectivity. | lld:pubmed |
| pubmed-article:9075929 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9075929 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9075929 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9075929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9075929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9075929 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9075929 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:9075929 | pubmed:author | pubmed-author:SassGG | lld:pubmed |
| pubmed-article:9075929 | pubmed:author | pubmed-author:PeterlinB MBM | lld:pubmed |
| pubmed-article:9075929 | pubmed:author | pubmed-author:Cheng-MayerCC | lld:pubmed |
| pubmed-article:9075929 | pubmed:author | pubmed-author:WillboldDD | lld:pubmed |
| pubmed-article:9075929 | pubmed:author | pubmed-author:BaurA SAS | lld:pubmed |
| pubmed-article:9075929 | pubmed:author | pubmed-author:LaffertBB | lld:pubmed |
| pubmed-article:9075929 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9075929 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:9075929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9075929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9075929 | pubmed:pagination | 283-91 | lld:pubmed |
| pubmed-article:9075929 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9075929 | pubmed:meshHeading | pubmed-meshheading:9075929-... | lld:pubmed |
| pubmed-article:9075929 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9075929 | pubmed:articleTitle | The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. | lld:pubmed |
| pubmed-article:9075929 | pubmed:affiliation | Institut für Klinische und Molekulare Virologie, Universität Erlangen/Nürnberg, Erlangen, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:9075929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9075929 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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