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pubmed-article:9075786pubmed:abstractTextA study was made of the in vitro effects of recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft agar clonogenic assay. Stimulation of megakaryocyte numbers was seen in liquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration led to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming efficiencies was seen for the remaining 3 specimens. These results suggest that PEG-rHuMGDF will not stimulate tumour growth in vivo.lld:pubmed
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pubmed-article:9075786pubmed:articleTitleIn vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth.lld:pubmed
pubmed-article:9075786pubmed:affiliationCRC Department of Experimental Haematology, Christie Hospital, Manchester, UK.lld:pubmed
pubmed-article:9075786pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9075786pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed