| pubmed-article:9064346 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C0205329 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:9064346 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:9064346 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9064346 | pubmed:dateCreated | 1997-3-20 | lld:pubmed |
| pubmed-article:9064346 | pubmed:abstractText | A unique experimental model has been developed for dissecting the integrity of CD8+ T cell-mediated immunity to a persistent gammaherpesvirus under conditions of CD4+ T cell deficiency. Respiratory challenge of major histocompatibility complex class II -/- and +/+ C57BL/6J mice with the murine gammaherpesvirus 68 (MHV-68) leads to productive infection of both lung and adrenal epithelial cells. Virus titers peak within 5-10 d, and are no longer detected after day 15. Persistent, latent infection is established concurrently in splenic and lymph node B cells, with higher numbers of MHV-68+ lymphocytes being found in all lymphoid sites analyzed from the +/+ mice concurrent with the massive, but transient splenomegaly that occurred only in this group. From day 17, however, the numbers of infected B lymphocytes were consistently higher in the -/- group, while the frequency of this population diminished progressively in the +/+ controls. Infectious MHV-68 was again detected in the respiratory tract and the adrenals of the -/- (but not the +/+) mice from day 22 after infection. The titers in these sites rose progressively, with the majority of the -/- mice dying between days 120 and 133. Even so, some CD8+ effectors were still functioning as late as 100 d after infection. Depletion of CD8+ T cells at this stage led to higher virus titers in the -/- lung, and to the development of wasting in some of the -/- mice. Elimination of the CD8+ T cells from the +/+ group (day 80) increased the numbers of MHV-68+ cells in the spleen, but did not reactivate the infection in the respiratory tract. The results are consistent with the interpretation that CD8+ T cell-mediated control of this persistent gammaherpesvirus is progressively lost in the absence of the CD4+ T cell subset. This parallels what may be happening in AIDS patients who develop Kaposi's sarcoma and various Epstein Barr virus associated disease processes. | lld:pubmed |
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| pubmed-article:9064346 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9064346 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9064346 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9064346 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9064346 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9064346 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9064346 | pubmed:author | pubmed-author:DohertyP CPC | lld:pubmed |
| pubmed-article:9064346 | pubmed:author | pubmed-author:BrooksJ WJW | lld:pubmed |
| pubmed-article:9064346 | pubmed:author | pubmed-author:SarawarS RSR | lld:pubmed |
| pubmed-article:9064346 | pubmed:author | pubmed-author:CardinR DRD | lld:pubmed |
| pubmed-article:9064346 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9064346 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9064346 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:9064346 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9064346 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9064346 | pubmed:pagination | 863-71 | lld:pubmed |
| pubmed-article:9064346 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9064346 | pubmed:year | 1996 | lld:pubmed |
