| pubmed-article:9062351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9062351 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9062351 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9062351 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:9062351 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:9062351 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:9062351 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
| pubmed-article:9062351 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9062351 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9062351 | pubmed:dateCreated | 1997-4-4 | lld:pubmed |
| pubmed-article:9062351 | pubmed:abstractText | Resting lymphocyte survival is dependent upon the expression of Bcl-2, yet the factors responsible for maintaining lymphocyte Bcl-2 protein expression in vivo are largely unknown. Natural killer (NK) cells are bone marrow-derived lymphocytes that constitutively express the beta and common gamma(c) subunits of the IL-2 receptor (R) as a heterodimer with intermediate affinity for IL-2. IL-15 also binds to IL-2Rbeta gamma(c) and is much more abundant in normal tissues than IL-2. Mice that lack the IL-2 gene have NK cells, whereas mice and humans that lack IL-2R gamma(c) do not have NK cells. Further, treatment of mice with an antibody directed against IL-2Rbeta results in a loss of the NK cell compartment. These data suggest that a cytokine other than IL-2, which binds to IL-2Rbeta gamma(c), is important for NK cell development and survival in vivo. In the current report, we show that the recently described IL-15R(alpha) subunit cooperates with IL-2Rbeta gamma(c) to transduce an intracellular signal at picomolar concentrations of IL-15. We demonstrate that resting human NK cells express IL-15R(alpha) mRNA and further, that picomolar amounts of IL-15 can sustain NK cell survival for up to 8 d in the absence of serum. NK cell survival was not sustained by other monocyte-derived factors (i.e., TNF-alpha, IL-1beta, IL-10, IL-12) nor by cytokines known to use gamma(c) for signaling (i.e., IL-4, IL-7, IL-9, IL- 13). One mechanism by which IL-15 promotes NK cell survival may involve the maintenance of Bcl-2 protein expression. Considering these functional properties of IL-15 and the fact that it is produced by bone marrow stromal cells and activated monocytes, we propose that IL-15 may function as an NK cell survival factor in vivo. | lld:pubmed |
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| pubmed-article:9062351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9062351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9062351 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9062351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9062351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9062351 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9062351 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:CroceC MCM | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:BaumannHH | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:CarsonW EWE | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:CaligiuriM... | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:LamC BCB | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:HaldarSS | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:LindemannM... | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:FehnigerT ATA | lld:pubmed |
| pubmed-article:9062351 | pubmed:author | pubmed-author:EckhertKK | lld:pubmed |
| pubmed-article:9062351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9062351 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9062351 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:9062351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9062351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9062351 | pubmed:pagination | 937-43 | lld:pubmed |
| pubmed-article:9062351 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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