| pubmed-article:9061645 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9061645 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9061645 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:9061645 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:9061645 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:9061645 | lifeskim:mentions | umls-concept:C1157570 | lld:lifeskim |
| pubmed-article:9061645 | lifeskim:mentions | umls-concept:C1159482 | lld:lifeskim |
| pubmed-article:9061645 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9061645 | pubmed:dateCreated | 1997-6-5 | lld:pubmed |
| pubmed-article:9061645 | pubmed:abstractText | 1. Human umbilical vein endothelial cells were challenged acutely with adenosine and its analogues to examine whether adenosine modulates L-arginine transport (system y+) and synthesis of nitric oxide (NO) and prostacyclin (PGI2). 2. L-Arginine transport was stimulated by adenosine (10 microM, 2 min) and the A2-receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS-21680; 100 nM), but not by the A1-receptor agonist N6-cyclopentyladenosine (CPA). 3. Activation of L-arginine transport was inhibited by the A2-receptor antagonists ZM-241385 and 3,7-dimethyl-1-propargylxanthine (DMPX), but unaffected by the A1-receptor antagonists 8-cyclopentyl-1,3-dipropylxanthine and 8-phenyltheophylline or the adenosine transport inhibitor nitrobenzylthioinosine. 4. Adenosine and CGS-21680 evoked a rapid membrane hyperpolarization. 5. Adenosine and CGS-21680 induced increases in intracellular cGMP levels, whereas release of PGI2 was unaffected. NG-nitro-L-arginine methyl ester (an NO synthase inhibitor) and the A2-receptor antagonists ZM-241385 and DMPX prevented increases in cGMP accumulation. 6. Our findings provide the first evidence that activation of human fetal endothelial cell A2-purinoceptors, but not A1-purinoceptors, leads to a membrane hyperpolarization and stimulation of basal rates of L-arginine transport and NO biosynthesis. | lld:pubmed |
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| pubmed-article:9061645 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9061645 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9061645 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9061645 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9061645 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9061645 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9061645 | pubmed:author | pubmed-author:YudilevichD... | lld:pubmed |
| pubmed-article:9061645 | pubmed:author | pubmed-author:MannG EGE | lld:pubmed |
| pubmed-article:9061645 | pubmed:author | pubmed-author:SobreviaLL | lld:pubmed |
| pubmed-article:9061645 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9061645 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9061645 | pubmed:volume | 499 ( Pt 1) | lld:pubmed |
| pubmed-article:9061645 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9061645 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9061645 | pubmed:pagination | 135-40 | lld:pubmed |
| pubmed-article:9061645 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
| pubmed-article:9061645 | pubmed:meshHeading | pubmed-meshheading:9061645-... | lld:pubmed |
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| pubmed-article:9061645 | pubmed:meshHeading | pubmed-meshheading:9061645-... | lld:pubmed |
| pubmed-article:9061645 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9061645 | pubmed:articleTitle | Activation of A2-purinoceptors by adenosine stimulates L-arginine transport (system y+) and nitric oxide synthesis in human fetal endothelial cells. | lld:pubmed |
| pubmed-article:9061645 | pubmed:affiliation | Vascular Biology Research Centre, King's College, London, UK. l.sobrevia@kcl.ac.uk | lld:pubmed |
| pubmed-article:9061645 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9061645 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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