| pubmed-article:9058831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9058831 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9058831 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:9058831 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9058831 | lifeskim:mentions | umls-concept:C0255998 | lld:lifeskim |
| pubmed-article:9058831 | lifeskim:mentions | umls-concept:C1514758 | lld:lifeskim |
| pubmed-article:9058831 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:9058831 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9058831 | pubmed:dateCreated | 1997-4-2 | lld:pubmed |
| pubmed-article:9058831 | pubmed:abstractText | Adenosine has both pro- and anti-inflammatory effects on neutrophils. Exposure of cultured neutrophils to 2-chloroadenosine or 5'-N-ethylcarboxamidoadenosine (NECA) decreased apoptosis after 16 h, with half-maximal responses for NECA and 2-chloroadenosine of 7.1 +/- 7.7 and 59.0 +/- 32.0 nM, respectively. Adenosine receptor agonists exhibited a rank order of potency for decreasing apoptosis of 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) > NECA > or = 2-chloro-N6-cyclopentyladenosine >> 2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide, which is consistent with the affinity order profile established for human A2a receptors. The reduction in apoptosis in cultured neutrophils at 16 h by CGS 21680 was due to a delay in apoptosis. The addition of CGS 21680 (100 nM) increased the half-life for the appearance of apoptosis from 10.9 +/- 3.1 to 21.0 +/- 1.0 h. Addition of the non-xanthine phosphodiesterase inhibitor 4-(3-butoxy-4-methoxybenzyl)-2-imidazalidinone (Ro-20-1724; 1 microM) enhanced the effects of CGS 21680 at all agonist concentrations. PGE1 (10 microM), PGE2 (0.1-10 microM), and dibutyryl cAMP (5-500 microM) all decreased apoptosis in cultured neutrophils. The enhancement of the effect of adenosine by a phosphodiesterase inhibitor and the similar actions of PGE2, PGE1, and dibutyryl cAMP suggest that this decrease in apoptosis may be mediated by a cAMP-dependent pathway. | lld:pubmed |
| pubmed-article:9058831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9058831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9058831 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9058831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9058831 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9058831 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9058831 | pubmed:author | pubmed-author:WalkerB ABA | lld:pubmed |
| pubmed-article:9058831 | pubmed:author | pubmed-author:FoxK PKP | lld:pubmed |
| pubmed-article:9058831 | pubmed:author | pubmed-author:JacobsonM AMA | lld:pubmed |
| pubmed-article:9058831 | pubmed:author | pubmed-author:RocchiniCC | lld:pubmed |
| pubmed-article:9058831 | pubmed:author | pubmed-author:BooneR HRH | lld:pubmed |
| pubmed-article:9058831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9058831 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9058831 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:9058831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9058831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9058831 | pubmed:pagination | 2926-31 | lld:pubmed |
| pubmed-article:9058831 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9058831 | pubmed:meshHeading | pubmed-meshheading:9058831-... | lld:pubmed |
| pubmed-article:9058831 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9058831 | pubmed:articleTitle | Adenosine A2a receptor activation delays apoptosis in human neutrophils. | lld:pubmed |
| pubmed-article:9058831 | pubmed:affiliation | University of British Columbia Pulmonary Research Laboratory, Vancouver, Canada. | lld:pubmed |
| pubmed-article:9058831 | pubmed:publicationType | Journal Article | lld:pubmed |
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