| pubmed-article:9057984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0038317 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0025876 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0038296 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0066478 | lld:lifeskim |
| pubmed-article:9057984 | lifeskim:mentions | umls-concept:C0599473 | lld:lifeskim |
| pubmed-article:9057984 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9057984 | pubmed:dateCreated | 1997-7-8 | lld:pubmed |
| pubmed-article:9057984 | pubmed:abstractText | Pharmacokinetics of metyrapone and metyrapol enantiomers was studied in the rat to determine the stereoselective reductive metabolism of metyrapone. The HPLC method using a chiral column was developed for the stereoselective analysis of metyrapol enantiomers in rat plasma. The AUC ratio of (-)- and (+)-metyrapol appeared in rat plasma after i.v. administration of metyrapone was about 3:1. The interconversion of (-)- or (+)-metyrapol to its antipode was negligible, and the reverse reaction from metyrapol to metyrapone was insignificant. There were similar kinetic parameters of (-)-metyrapol to those of (+)-metyrapol after i.v. administration of racemic metyrapol. These results indicate metyrapone displays product-stereoselective reductive metabolism in the rat. The inhibition of steroid 11 beta-hydroxylase by metyrapone, racemic metyrapol, (-)-metyrapol or (+)-metyrapol was analyzed in rat adrenal homogenates. Metyrapol was equally as potent as metyrapone in the inhibition of steroid 11 beta-hydroxylase and each enantiomer of metyrapol showed similar inhibitory activity on the rat adrenal steroid 11 beta-hydroxylase. These results indicate there is an insignificant difference in the inhibitory effects on steroid 11 beta-hydroxylase of metyrapol enantiomers, and that the inhibitory effects of metyrapol may be involved in the pharmacological activity of metyrapone in vivo. | lld:pubmed |
| pubmed-article:9057984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9057984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9057984 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9057984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9057984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9057984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9057984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9057984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9057984 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9057984 | pubmed:issn | 0918-6158 | lld:pubmed |
| pubmed-article:9057984 | pubmed:author | pubmed-author:AsadaSS | lld:pubmed |
| pubmed-article:9057984 | pubmed:author | pubmed-author:FukuyamaYY | lld:pubmed |
| pubmed-article:9057984 | pubmed:author | pubmed-author:NagamineSS | lld:pubmed |
| pubmed-article:9057984 | pubmed:author | pubmed-author:IwakawaSS | lld:pubmed |
| pubmed-article:9057984 | pubmed:author | pubmed-author:MatsuzawaRR | lld:pubmed |
| pubmed-article:9057984 | pubmed:author | pubmed-author:MaetaniKK | lld:pubmed |
| pubmed-article:9057984 | pubmed:author | pubmed-author:HorisakaEE | lld:pubmed |
| pubmed-article:9057984 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9057984 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:9057984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9057984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9057984 | pubmed:pagination | 188-92 | lld:pubmed |
| pubmed-article:9057984 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:meshHeading | pubmed-meshheading:9057984-... | lld:pubmed |
| pubmed-article:9057984 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9057984 | pubmed:articleTitle | Stereoselective reductive metabolism of metyrapone and inhibitory activity of metyrapone metabolites, metyrapol enantiomers, on steroid 11 beta-hydroxylase in the rat. | lld:pubmed |
| pubmed-article:9057984 | pubmed:affiliation | Department of Pharmaceutics, Kobe Pharmaceutical University, Japan. | lld:pubmed |
| pubmed-article:9057984 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9057984 | lld:pubmed |
