| pubmed-article:9056002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C1261473 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C1513846 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0007585 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0018321 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0028621 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0050175 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0260127 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0384226 | lld:lifeskim |
| pubmed-article:9056002 | lifeskim:mentions | umls-concept:C0529787 | lld:lifeskim |
| pubmed-article:9056002 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9056002 | pubmed:dateCreated | 1997-6-2 | lld:pubmed |
| pubmed-article:9056002 | pubmed:abstractText | From a side-by-side comparative study, the acyclic nucleoside phosphonates (R)-9-(2-phosphonylmethoxypropyl)adenine [(R)-PMPA] and 9-(2-methylidene-3-phosphonomethoxypropyl)guanine (MDL 74,968) proved more selective in their inhibitory effect on human immunodeficiency virus types 1 and 2, feline immunodeficiency virus, and Moloney murine sarcoma virus (MSV) in cell cultures than the 9-(2-phosphonylmethoxyethyl) derivatives of adenine (PMEA) and guanine (PMEG). In particular, PMEG proved quite toxic. PMEA, (R)-PMPA, and MDL 74,968 afforded a marked delay in MSV-induced tumor initiation in MSV-infected newborn NMRI mice and substantially delayed associated animal death at doses as low as 4 to 10 mg/kg of body weight. Treatment of the NMRI mice with PMEA, (R)-PMPA, and MDL 74,968 at 25 or 50 mg/kg resulted in a high percentage of long-term survivors. | lld:pubmed |
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| pubmed-article:9056002 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9056002 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9056002 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9056002 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9056002 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:HartmannKK | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:De ClercqEE | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:CasaraPP | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:BalzariniJJ | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:WitvrouwMM | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:NavéJ FJF | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:EgberinkHH | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:PannecouqueCC | lld:pubmed |
| pubmed-article:9056002 | pubmed:author | pubmed-author:VahlenkampTT | lld:pubmed |
| pubmed-article:9056002 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9056002 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:9056002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9056002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9056002 | pubmed:pagination | 611-6 | lld:pubmed |
| pubmed-article:9056002 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9056002 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9056002 | pubmed:articleTitle | Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice. | lld:pubmed |
| pubmed-article:9056002 | pubmed:affiliation | Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium. | lld:pubmed |
| pubmed-article:9056002 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9056002 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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