| pubmed-article:9053458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:9053458 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:9053458 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9053458 | pubmed:dateCreated | 1997-3-13 | lld:pubmed |
| pubmed-article:9053458 | pubmed:abstractText | Microglial cells express a peculiar plasma membrane receptor for extracellular ATP, named P2Z/P2X7 purinergic receptor, that triggers massive transmembrane ion fluxes and a reversible permeabilization of the plasma membrane to hydrophylic molecules of up to 900 dalton molecule weight and eventual cell death (Di Virgilio, F. 1995. Immunol. Today, 16:524-528). The physiological role of this newly cloned (Surprenant, A., F. Rassendren, E. Kawashima, R. A. North and G. Buell, 1996. Science (Wash. DC). 272:735-737) cytolytic receptor is unknown. In vitro and in vivo activation of the macrophage and microglial cell P2Z/P2X7 receptor by exogenous ATP causes a large and rapid release of mature IL-1 beta. In the present report we investigated the role of microglial P2Z/P2X7 receptor in IL-1 beta release triggered by LPS. Our data suggest that LPS-dependent IL-1 beta release involves activation of this purinergic receptor as it is inhibited by the selective P2Z/P2X7 blocker oxidized ATP and modulated by ATP-hydrolyzing enzymes such as apyrase or hexokinase. Furthermore, microglial cells release ATP when stimulated with LPS. LPS-dependent release of ATP is also observed in monocyte-derived human macrophages. It is suggested that bacterial endotoxin activates an autocrine/paracrine loop that drives ATP-dependent IL-1 beta secretion. | lld:pubmed |
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| pubmed-article:9053458 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9053458 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9053458 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9053458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9053458 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9053458 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9053458 | pubmed:author | pubmed-author:Di VirgilioFF | lld:pubmed |
| pubmed-article:9053458 | pubmed:author | pubmed-author:FerrariDD | lld:pubmed |
| pubmed-article:9053458 | pubmed:author | pubmed-author:ChiozziPP | lld:pubmed |
| pubmed-article:9053458 | pubmed:author | pubmed-author:HanauSS | lld:pubmed |
| pubmed-article:9053458 | pubmed:author | pubmed-author:FalzoniSS | lld:pubmed |
| pubmed-article:9053458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9053458 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:9053458 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:9053458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9053458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9053458 | pubmed:pagination | 579-82 | lld:pubmed |
| pubmed-article:9053458 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9053458 | pubmed:meshHeading | pubmed-meshheading:9053458-... | lld:pubmed |
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| pubmed-article:9053458 | pubmed:meshHeading | pubmed-meshheading:9053458-... | lld:pubmed |
| pubmed-article:9053458 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9053458 | pubmed:articleTitle | Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. | lld:pubmed |
| pubmed-article:9053458 | pubmed:affiliation | Institute of General Pathology, University of Ferrara, Italy. | lld:pubmed |
| pubmed-article:9053458 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9053458 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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