| pubmed-article:9050749 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C1522496 | lld:lifeskim |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:9050749 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9050749 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9050749 | pubmed:dateCreated | 1997-6-24 | lld:pubmed |
| pubmed-article:9050749 | pubmed:abstractText | The authors have studied mechanisms which could be involved in the sustained activation of the hypothalamus-pituitary-adrenal (HPA) axis during continuous infusion of rats with recombinant human interleukin-1beta (IL-1beta). First, the effects of 3 days of intracerebroventricular (i.c.v.) infusion of rats with IL-1 on plasma adrenocorticotropin (ACTH) and corticosterone (B) levels were investigated. Thereafter, changes in plasma ACTH and B levels were followed in rats intraperitoneally (i.p.) infused with IL-1beta after immunoneutralization of corticotropin-releasing hormone (CRH), hypophysectomy (HPX), macrophage depletion using dichloromethylene diphosphonate (Cl2MDP)-containing liposomes, adrenalectomy (ADX) and dexamethasone (DEX) administration, respectively. Infusion of IL-1beta i.c.v., even in doses as low as 0.1 microg/day, induced significant increases in plasma ACTH and B levels. HPX and ADX rats died within 18 h after starting the IL-1beta infusion (0.5 microg/day). Immunoneutralization of CRH significantly decreased and macrophage depletion significantly increased the stimulation of the HPA axis by IL-1 (4.0 microg/day). Administration of high doses of DEX completely abolished the stimulation of the HPA axis by IL-1beta (2.0 microg/day). The present study demonstrates that lower doses of IL-1beta were able to activate the HPA axis when infused i.c.v. compared with i.p. Regarding stimulation of the HPA axis by chronic i.p. infusion of IL-1beta the present study: (1) provides evidence that the CRH system is involved; (2) provides no evidence for a direct stimulatory effect of IL-1beta on the release of B by the adrenal gland which is of sufficient magnitude to resist the stress of chronic i.p. IL-1beta infusion; (3) shows that endogenous macrophage-derived mediators, induced by i.p. IL-1beta infusion, express an overall inhibitory rather than a stimulatory effect on the activity of the HPA axis; (4) demonstrates that exogenous administration of DEX blocks the effect of IL-1beta, which fits well in the concept of an immunoregulatory feedback between IL-1beta and glucocorticoids. | lld:pubmed |
| pubmed-article:9050749 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9050749 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9050749 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9050749 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9050749 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:9050749 | pubmed:author | pubmed-author:SweetC SCS | lld:pubmed |
| pubmed-article:9050749 | pubmed:author | pubmed-author:TildersF JFJ | lld:pubmed |
| pubmed-article:9050749 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:9050749 | pubmed:author | pubmed-author:HermusA RAR | lld:pubmed |
| pubmed-article:9050749 | pubmed:author | pubmed-author:PesmanG JGJ | lld:pubmed |
| pubmed-article:9050749 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9050749 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9050749 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9050749 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9050749 | pubmed:pagination | 910-9 | lld:pubmed |
| pubmed-article:9050749 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9050749 | pubmed:meshHeading | pubmed-meshheading:9050749-... | lld:pubmed |
| pubmed-article:9050749 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9050749 | pubmed:articleTitle | Chronic stimulation of the hypothalamus-pituitary-adrenal axis in rats by interleukin 1beta: central and peripheral mechanisms. | lld:pubmed |
| pubmed-article:9050749 | pubmed:affiliation | Department of Medicine, University Hospital Nijmegen, The Netherlands. | lld:pubmed |
| pubmed-article:9050749 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9050749 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9050749 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9050749 | lld:pubmed |
