| pubmed-article:9045879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9045879 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9045879 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:9045879 | lifeskim:mentions | umls-concept:C0520863 | lld:lifeskim |
| pubmed-article:9045879 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9045879 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:9045879 | lifeskim:mentions | umls-concept:C0024468 | lld:lifeskim |
| pubmed-article:9045879 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9045879 | pubmed:dateCreated | 1997-3-20 | lld:pubmed |
| pubmed-article:9045879 | pubmed:abstractText | Sarcomere relaxation depends on dissociation of actin and myosin, which is regulated by a number of factors, including intracellular [MgATP] as well as MgATP hydrolysis products [MgADP] and inorganic phosphate [Pi], pHi, and cytosolic calcium concentration ([Ca2+]c). To distinguish the contribution of MgADP from the other regulators in the development of diastolic dysfunction, we used a strategy to increase free [MgADP] without changing [MgATP], [Pi], or pHi. This was achieved by applying a low dose of iodoacetamide to selectively inhibit the creatine kinase activity in isolated perfused rat hearts. [MgATP], [MgADP], [Pi], and [H+] were determined using 31P NMR spectroscopy. The [Ca2+]c and the glycolytic rate were also measured. We observed an approximately threefold increase in left ventricular end diastolic pressure (LVEDP) and 38% increase in the time constant of pressure decay (P < 0.05) in these hearts, indicating a significant impairment of diastolic function. The increase in LVEDP was closely related to the increase in free [MgADP]. Rate of glycolysis was not changed, and [Ca2+]c increased by 16%, which cannot explain the severity of diastolic dysfunction. Thus, our data indicate that MgADP contributes significantly to diastolic dysfunction, possibly by slowing the rate of cross-bridge cycling. | lld:pubmed |
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| pubmed-article:9045879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9045879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9045879 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9045879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9045879 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9045879 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9045879 | pubmed:author | pubmed-author:IngwallJ SJS | lld:pubmed |
| pubmed-article:9045879 | pubmed:author | pubmed-author:TibiLL | lld:pubmed |
| pubmed-article:9045879 | pubmed:author | pubmed-author:SpindlerMM | lld:pubmed |
| pubmed-article:9045879 | pubmed:author | pubmed-author:CamachoS ASA | lld:pubmed |
| pubmed-article:9045879 | pubmed:author | pubmed-author:HalowJ MJM | lld:pubmed |
| pubmed-article:9045879 | pubmed:author | pubmed-author:ChristeM EME | lld:pubmed |
| pubmed-article:9045879 | pubmed:author | pubmed-author:HopkinsJ CJC | lld:pubmed |
| pubmed-article:9045879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9045879 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9045879 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:9045879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9045879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9045879 | pubmed:pagination | 745-51 | lld:pubmed |
| pubmed-article:9045879 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9045879 | pubmed:meshHeading | pubmed-meshheading:9045879-... | lld:pubmed |
| pubmed-article:9045879 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9045879 | pubmed:articleTitle | Role of MgADP in the development of diastolic dysfunction in the intact beating rat heart. | lld:pubmed |
| pubmed-article:9045879 | pubmed:affiliation | NMR Laboratory for Physiological Chemistry, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. rong@bustoff.bwh.harvard.edu | lld:pubmed |
| pubmed-article:9045879 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9045879 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9045879 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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