| pubmed-article:9044030 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9044030 | lifeskim:mentions | umls-concept:C0002679 | lld:lifeskim |
| pubmed-article:9044030 | lifeskim:mentions | umls-concept:C0016277 | lld:lifeskim |
| pubmed-article:9044030 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9044030 | lifeskim:mentions | umls-concept:C0003235 | lld:lifeskim |
| pubmed-article:9044030 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:9044030 | lifeskim:mentions | umls-concept:C0053089 | lld:lifeskim |
| pubmed-article:9044030 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9044030 | pubmed:dateCreated | 1997-5-15 | lld:pubmed |
| pubmed-article:9044030 | pubmed:abstractText | The in-vivo antifungal activity of benanomicin A administered intravenously or subcutaneously was compared with that of amphotericin B and fluconazole using animal models of systemic infections with Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. The efficacy of benanomicin A in C. albicans infection was more pronounced when administered in multiple doses than in a single dose. This was also true of fluconazole, but not of amphotericin B, which showed no difference between single and multiple dosings. Benanomcin A eradicated C. albicans cells from the kidneys of infected mice in a manner comparable to that of amphotericin B, but more effectively than fluconazole. The histopathological findings obtained from the kidneys of the C. albicans-infected mice confirmed the therapeutic efficacy of benanomicin A. The subcutaneous ED50 values of benanomicin A were 1.30 mg/kg/day (C. albicans) and 19.0 mg/kg/day (A. fumigatus) which were intermediate between those of amphotericin B and fluconazole in the two models. The subcutaneous ED50 value of benanomicin A for C. neoformans was 21.5 mg/kg/day, which was higher than that of amphotericin B. | lld:pubmed |
| pubmed-article:9044030 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9044030 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9044030 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9044030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9044030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9044030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9044030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9044030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9044030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9044030 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9044030 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9044030 | pubmed:issn | 0305-7453 | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:WatanabeMM | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:YamaguchiHH | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:TakeuchiTT | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:UchidaKK | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:KondoSS | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:InouyeSS | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:OhtsukaKK | lld:pubmed |
| pubmed-article:9044030 | pubmed:author | pubmed-author:OrikasaYY | lld:pubmed |
| pubmed-article:9044030 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9044030 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:9044030 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9044030 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9044030 | pubmed:pagination | 71-7 | lld:pubmed |
| pubmed-article:9044030 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
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| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
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| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
| pubmed-article:9044030 | pubmed:meshHeading | pubmed-meshheading:9044030-... | lld:pubmed |
| pubmed-article:9044030 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9044030 | pubmed:articleTitle | The in-vivo activity of an antifungal antibiotic, benanomicin A, in comparison with amphotericin B and fluconazole. | lld:pubmed |
| pubmed-article:9044030 | pubmed:affiliation | Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan. | lld:pubmed |
| pubmed-article:9044030 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9044030 | pubmed:publicationType | Comparative Study | lld:pubmed |
