| pubmed-article:9043635 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9043635 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:9043635 | lifeskim:mentions | umls-concept:C0010536 | lld:lifeskim |
| pubmed-article:9043635 | lifeskim:mentions | umls-concept:C0018338 | lld:lifeskim |
| pubmed-article:9043635 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:9043635 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9043635 | lifeskim:mentions | umls-concept:C1276855 | lld:lifeskim |
| pubmed-article:9043635 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9043635 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9043635 | pubmed:dateCreated | 1997-6-13 | lld:pubmed |
| pubmed-article:9043635 | pubmed:abstractText | An elastin-derived peptide with an average molecular mass of 25 kDa was shown to induce monocyte chemotaxis at the optimal concentration of 10(-1) micrograms/ml. Homologous deactivation test showed that monocytes exposed to the elastin-derived peptide at 10(-1) micrograms/ml lost their chemotactic responsiveness when reexposed to the same stimulus. In conjunction with chemotactic response to the elastin-derived peptide, intracellular guanosine 3', 5'-monophosphate (cGMP) levels were enhanced but intracellular adenosine 3', 5'-monophosphate (cAMP) levels were not. The monocyte migration induced by the elastin-derived peptide was inhibited by cGMP dependent protein kinase (PKG) inhibitor, but not by cAMP dependent protein kinase inhibitor and protein kinase C inhibitor. These results suggest that the elastin-derived peptide induces monocyte chemotaxis by increasing the level of cGMP, followed by activating PKG. | lld:pubmed |
| pubmed-article:9043635 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9043635 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9043635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9043635 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9043635 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9043635 | pubmed:issn | 1039-9712 | lld:pubmed |
| pubmed-article:9043635 | pubmed:author | pubmed-author:UemuraYY | lld:pubmed |
| pubmed-article:9043635 | pubmed:author | pubmed-author:OkamotoKK | lld:pubmed |
| pubmed-article:9043635 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9043635 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:9043635 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9043635 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9043635 | pubmed:pagination | 57-64 | lld:pubmed |
| pubmed-article:9043635 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
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| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:meshHeading | pubmed-meshheading:9043635-... | lld:pubmed |
| pubmed-article:9043635 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9043635 | pubmed:articleTitle | Elastin-derived peptide induces monocyte chemotaxis by increasing intracellular cyclic GMP level and activating cyclic GMP dependent protein kinase. | lld:pubmed |
| pubmed-article:9043635 | pubmed:affiliation | Department of Biochemical Engineering and Science, Kyushu Institute of Technology, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:9043635 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9043635 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9043635 | lld:pubmed |
