| pubmed-article:9042918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9042918 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:9042918 | lifeskim:mentions | umls-concept:C0752105 | lld:lifeskim |
| pubmed-article:9042918 | lifeskim:mentions | umls-concept:C1846237 | lld:lifeskim |
| pubmed-article:9042918 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:9042918 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:9042918 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9042918 | pubmed:dateCreated | 1997-3-18 | lld:pubmed |
| pubmed-article:9042918 | pubmed:abstractText | An autosomal recessive form of juvenile Parkinsonism (AR-JP) (MIM 600116) is a levodopa-responsive Parkinsonism whose pathological finding is a highly selective degeneration of dopaminergic neurons in the zona compacta of the substantia nigra. By linkage analysis of diallelic polymorphism of the Mn-superoxide dismutase gene (SOD2), we found a family with AR-JP showing perfect segregation of the disease with the SOD2 locus. By extending the linkage analysis to 13 families with AR-JP, we discovered strong evidence for the localization of the AR-JP gene at chromosome 6q25.2-27, including the SOD2 locus, with the maximal cumulative pairwise LOD scores of 7.26 and 7.71 at D6S305 (theta = .03) and D6S253 (theta = .02), respectively. Observation of obligate recombination events, as well as multipoint linkage analysis, placed the AR-JP gene in a 17-cM interval between D6S437 and D6S264. Delineation of the AR-JP gene will be an important step toward our understanding of the molecular mechanism underlying selective degeneration of the nigral neurons. | lld:pubmed |
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| pubmed-article:9042918 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9042918 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9042918 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9042918 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9042918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9042918 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9042918 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:YamamuraYY | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:KondoTT | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:MoriHH | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:SaitoMM | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:NakamuraSS | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:IgarashiSS | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:KobayashiTT | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:TanakaHH | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:TakanoHH | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:TsujiSS | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:MizunoYY | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:KuzuharaSS | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:IshikawaAA | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:YokochiMM | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:MizutaniYY | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:KoikeRR | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:SanpeiKK | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:Nakagawa-Hatt... | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:MatsumineHH | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:Shimoda-Matsu... | lld:pubmed |
| pubmed-article:9042918 | pubmed:author | pubmed-author:SchäfferA AAA | lld:pubmed |
| pubmed-article:9042918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9042918 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:9042918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9042918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9042918 | pubmed:pagination | 588-96 | lld:pubmed |
| pubmed-article:9042918 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9042918 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9042918 | pubmed:articleTitle | Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27. | lld:pubmed |
| pubmed-article:9042918 | pubmed:affiliation | Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan. | lld:pubmed |
| pubmed-article:9042918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9042918 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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