| pubmed-article:9041044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0029923 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0176751 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0015083 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:9041044 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:9041044 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9041044 | pubmed:dateCreated | 1997-5-19 | lld:pubmed |
| pubmed-article:9041044 | pubmed:abstractText | Ovalbumin (OVA) was chemically modified with poly(ethylene glycol) (PEG) derivatives: activated PEG2, 2,4-bis[O-methoxypoly(ethylene glycol)]-6-chloro-s-triazine and activated PM13, copolymer of poly(oxyethylene) allyl methyl diether and maleic anhydride. Pretreatment of BALB/c mice with PEG2- or PM13-OVA suppressed the production of both IgG- and IgE-class anti-OVA antibodies induced by subsequent immunizations with unmodified OVA. PEG2-OVA had higher potency to suppress OVA-specific immune response than PM13-OVA. Although extensive modification (62%) of amino groups in the OVA molecule with activated PEG2 was required to diminish most of its immunoreactivity towards anti-OVA antibodies, only a low degree of modification (27%) was sufficient to induce tolerogenicity to OVA. Thus, the loss of immunoreactivity of PEG2-OVA was not prerequisite for its tolerogenic capacity. Moreover, the use of completely denatured PEG2-OVA immunogen lead to the loss of its ability to induce immune tolerance to native OVA. These observations are discussed in relation to the regulatory mechanism of immune response. | lld:pubmed |
| pubmed-article:9041044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9041044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9041044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9041044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9041044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9041044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9041044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9041044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9041044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9041044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9041044 | pubmed:issn | 0920-5063 | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:SaitoTT | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:InadaYY | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:SekineTT | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:MatsushimaAA | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:NishimuraHH | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:KoderaYY | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:UrushibaraTT | lld:pubmed |
| pubmed-article:9041044 | pubmed:author | pubmed-author:HirotoMM | lld:pubmed |
| pubmed-article:9041044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9041044 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:9041044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9041044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9041044 | pubmed:pagination | 311-21 | lld:pubmed |
| pubmed-article:9041044 | pubmed:dateRevised | 2008-2-20 | lld:pubmed |
| pubmed-article:9041044 | pubmed:meshHeading | pubmed-meshheading:9041044-... | lld:pubmed |
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| pubmed-article:9041044 | pubmed:meshHeading | pubmed-meshheading:9041044-... | lld:pubmed |
| pubmed-article:9041044 | pubmed:meshHeading | pubmed-meshheading:9041044-... | lld:pubmed |
| pubmed-article:9041044 | pubmed:meshHeading | pubmed-meshheading:9041044-... | lld:pubmed |
| pubmed-article:9041044 | pubmed:meshHeading | pubmed-meshheading:9041044-... | lld:pubmed |
| pubmed-article:9041044 | pubmed:meshHeading | pubmed-meshheading:9041044-... | lld:pubmed |
| pubmed-article:9041044 | pubmed:meshHeading | pubmed-meshheading:9041044-... | lld:pubmed |
| pubmed-article:9041044 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9041044 | pubmed:articleTitle | Tolerogenic capacity of poly(ethylene glycol) (PEG)--modified ovalbumins in relation to their immunoreactivity towards anti-ovalbumin antibody. | lld:pubmed |
| pubmed-article:9041044 | pubmed:affiliation | Toin Human Science and Technology Center, Department of Materials Science and Technology, Toin University of Yokohama, Japan. | lld:pubmed |
| pubmed-article:9041044 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9041044 | lld:pubmed |
