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pubmed-article:9037225pubmed:abstractTextMortality after hepatectomy in rats increases markedly beyond the classic 2/3 resection from which complete recovery is the rule. Because an extremely small hepatocyte population can theoretically sustain life, we hypothesize that lethal liver failure after subtotal resection could be due to progressive injury occurring in the remnant liver. The obligatory increase in portal blood through the small remnant may be central to the pathogenesis because of sinusoidal injury and Kupffer's cell activation. To test this hypothesis an experimental study in rats was undertaken to characterize liver cell injury after lethal (85%) and nonlethal (70%) hepatectomy.lld:pubmed
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pubmed-article:9037225pubmed:articleTitleProgressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection.lld:pubmed
pubmed-article:9037225pubmed:affiliationLiver Transplant Program, University of California, San Francisco 94143-0780, USA.lld:pubmed
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