| pubmed-article:9036957 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C0206071 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9036957 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9036957 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9036957 | pubmed:dateCreated | 1997-3-11 | lld:pubmed |
| pubmed-article:9036957 | pubmed:abstractText | TNF is implicated in in vitro Ig production, but its role in vivo is not clearly defined. Our previous studies had shown that TNF-LT alpha double-deficient mice have defective IgM and IgG primary Ab responses to the T cell-dependent (TD) Ag SRBC. We now extend these studies to secondary responses and to T cell-independent (TI) B cell responses. Injections of the TD Ag SRBC did not induce germinal center formation in the spleen of TNF-LT alpha-deficient mice. Associated with the morphologic defect, there was a defective IgG Ab response and a secondary hyper-IgM response to the TD Ag in TNF-LT alpha-deficient mice. The response to the TI Ag type 2 DNP-alanyl-glycyl-glycyl-Ficoll was essentially absent in TNF-LT alpha-deficient mice, while that to the TI Ag type 1 TNP-LPS was significantly reduced only for IgG2b isotype. Transplantation of bone marrow cells from wild-type mice into irradiated TNF-LT alpha-deficient mice restored the formation of splenic germinal centers and corrected the IgM and IgG responses to both TD and TI Ags. These data suggest that TNF and/or LT alpha signaling are critically required for germinal center formation and for the IgM and IgG responses to both TD and TI type 2 Ags. | lld:pubmed |
| pubmed-article:9036957 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9036957 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9036957 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9036957 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9036957 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9036957 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9036957 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9036957 | pubmed:author | pubmed-author:Di PadovaFF | lld:pubmed |
| pubmed-article:9036957 | pubmed:author | pubmed-author:SchreierM HMH | lld:pubmed |
| pubmed-article:9036957 | pubmed:author | pubmed-author:Le HirMM | lld:pubmed |
| pubmed-article:9036957 | pubmed:author | pubmed-author:QuesniauxV... | lld:pubmed |
| pubmed-article:9036957 | pubmed:author | pubmed-author:RyffelBB | lld:pubmed |
| pubmed-article:9036957 | pubmed:author | pubmed-author:EugsterH PHP | lld:pubmed |
| pubmed-article:9036957 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9036957 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9036957 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:9036957 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9036957 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9036957 | pubmed:pagination | 2126-33 | lld:pubmed |
| pubmed-article:9036957 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9036957 | pubmed:meshHeading | pubmed-meshheading:9036957-... | lld:pubmed |
| pubmed-article:9036957 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9036957 | pubmed:articleTitle | Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice. | lld:pubmed |
| pubmed-article:9036957 | pubmed:affiliation | Institute of Pathology, University of Basel, Switzerland. | lld:pubmed |
| pubmed-article:9036957 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9036957 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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