| pubmed-article:9032329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9032329 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:9032329 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9032329 | lifeskim:mentions | umls-concept:C0919477 | lld:lifeskim |
| pubmed-article:9032329 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9032329 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9032329 | pubmed:dateCreated | 1997-3-18 | lld:pubmed |
| pubmed-article:9032329 | pubmed:abstractText | To understand the mechanism of p56lck protein downregulation observed in human T cells infected by human T-cell leukemia virus type 1 (HTLV-1), we have investigated the ability of the 3' end of the HTLV-1 genome as well as that of the tax and rex genes to modulate p56lck protein expression and p56lck mRNA synthesis. By using Jurkat T cells stably transfected with constructs that expressed either the 3' end of the HTLV-1 genome (JK C11-pMTEX), the tax gene (JK52-Tax) or the rex gene (JK9-Rex), we found that the expression of p40tax (Tax) was sufficient to modulate p56lck protein expression. Similarly, we found that the expression of the mRNA which encoded p56lck was repressed in Jurkat T cells which expressed Tax. This downregulation was shown to be proportional to the amount of tax mRNA found in the transfected cells, as evidenced by experiments that used cells (JPX-9) stably transfected with a tax gene driven by a cadmium-inducible promoter. Furthermore, cadmium induction of Tax in JPX-9 cells transiently transfected with a construct containing the chloramphenicol acetyltransferase (CAT) gene under control of the lck distal promoter (lck DP-CAT) resulted in the downregulation of CAT gene expression. In contrast, cadmium induction of Tax in JPX-9 cells transiently transfected with a CAT construct driven by a lck DP with a deletion extending from position -259 to -253 (a sequence corresponding to a putative E-Box) did not modulate CAT gene expression, suggesting that the effect of Tax on p56lck is mediated through an E-Box binding protein. | lld:pubmed |
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| pubmed-article:9032329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9032329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9032329 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9032329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9032329 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9032329 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9032329 | pubmed:author | pubmed-author:DevauxCC | lld:pubmed |
| pubmed-article:9032329 | pubmed:author | pubmed-author:GazzoloLL | lld:pubmed |
| pubmed-article:9032329 | pubmed:author | pubmed-author:Robert-Hebman... | lld:pubmed |
| pubmed-article:9032329 | pubmed:author | pubmed-author:Duc DodonMM | lld:pubmed |
| pubmed-article:9032329 | pubmed:author | pubmed-author:LemassonII | lld:pubmed |
| pubmed-article:9032329 | pubmed:author | pubmed-author:HamaiaSS | lld:pubmed |
| pubmed-article:9032329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9032329 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:9032329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9032329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9032329 | pubmed:pagination | 1975-83 | lld:pubmed |
| pubmed-article:9032329 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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