| pubmed-article:9027314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
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| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:9027314 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:9027314 | pubmed:issue | 5303 | lld:pubmed |
| pubmed-article:9027314 | pubmed:dateCreated | 1997-3-11 | lld:pubmed |
| pubmed-article:9027314 | pubmed:abstractText | Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria. | lld:pubmed |
| pubmed-article:9027314 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9027314 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9027314 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9027314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9027314 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9027314 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:JonesD PDP | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:YangJJ | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:LimPP | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:CaoPP | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:BhallaKK | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:IbradoA MAM | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:PengT ITI | lld:pubmed |
| pubmed-article:9027314 | pubmed:author | pubmed-author:KimC NCN | lld:pubmed |
| pubmed-article:9027314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9027314 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:9027314 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:9027314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9027314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9027314 | pubmed:pagination | 1129-32 | lld:pubmed |
| pubmed-article:9027314 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:9027314 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9027314 | pubmed:articleTitle | Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. | lld:pubmed |
| pubmed-article:9027314 | pubmed:affiliation | Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. | lld:pubmed |
| pubmed-article:9027314 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9027314 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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