| pubmed-article:9026437 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9026437 | lifeskim:mentions | umls-concept:C0006837 | lld:lifeskim |
| pubmed-article:9026437 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9026437 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9026437 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:9026437 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:9026437 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:9026437 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:9026437 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:9026437 | pubmed:dateCreated | 1997-2-19 | lld:pubmed |
| pubmed-article:9026437 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9026437 | pubmed:abstractText | A gene encoding a type I topoisomerase (TOP1) was isolated from Candida albicans, sequenced, and expressed in Saccharomyces cerevisiae. The TOP1 gene was identified from a C. albicans genomic library by hybridization with the product of a polymerase chain reaction with degenerate primer sets encoding regions conserved in other TOP1 genes. A clone containing an open reading frame of 2463 bp and predicted to encode a protein of 778 amino acids with sequence similarity to eukaryotic type I topoisomerases was identified. The C. albicans TOP1 gene restored camptothecin sensitivity and increased the topoisomerase activity in S. cerevisiae, indicating that the DNA fragment encodes a functional C. albicans topoisomerase I. | lld:pubmed |
| pubmed-article:9026437 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9026437 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9026437 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9026437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9026437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9026437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9026437 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9026437 | pubmed:month | May | lld:pubmed |
| pubmed-article:9026437 | pubmed:issn | 0378-1097 | lld:pubmed |
| pubmed-article:9026437 | pubmed:author | pubmed-author:TaylorAA | lld:pubmed |
| pubmed-article:9026437 | pubmed:author | pubmed-author:FosterLL | lld:pubmed |
| pubmed-article:9026437 | pubmed:author | pubmed-author:GiletJJ | lld:pubmed |
| pubmed-article:9026437 | pubmed:author | pubmed-author:SarthyA VAV | lld:pubmed |
| pubmed-article:9026437 | pubmed:author | pubmed-author:McGonigalTT | lld:pubmed |
| pubmed-article:9026437 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9026437 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9026437 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:9026437 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9026437 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9026437 | pubmed:pagination | 113-21 | lld:pubmed |
| pubmed-article:9026437 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9026437 | pubmed:meshHeading | pubmed-meshheading:9026437-... | lld:pubmed |
| pubmed-article:9026437 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9026437 | pubmed:articleTitle | Identification of the gene encoding DNA topoisomerase I from Candida albicans. | lld:pubmed |
| pubmed-article:9026437 | pubmed:affiliation | Antifungal Biology, Anti-infective Division, Abbott Laboratories, Abbott Park, IL 60064, USA. | lld:pubmed |
| pubmed-article:9026437 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9026437 | pubmed:publicationType | Comparative Study | lld:pubmed |
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