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pubmed-article:9023653pubmed:abstractTextThe effect of increasing meropenem concentrations up to 250 mg/L, as might occur if 3 g was given as a single daily intravenous dose, was investigated in terms of bactericidal activity, post antibiotic effect (PAE) and modified controlled effective regrowth time (mCERT). Increasing the meropenem concentration above 50 mg/L did not result in increased bacterial killing, while concentrations over 75 mg/L did not result in longer PAE or mCERT.lld:pubmed
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pubmed-article:9023653pubmed:articleTitleBactericidal activity, post antibiotic effect and modified controlled effective regrowth time of meropenem at high concentrations.lld:pubmed
pubmed-article:9023653pubmed:affiliationBristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust, UK. lesassays@ukneqasaa.win-uk.netlld:pubmed
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