| pubmed-article:9022982 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9022982 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:9022982 | lifeskim:mentions | umls-concept:C0010579 | lld:lifeskim |
| pubmed-article:9022982 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9022982 | pubmed:dateCreated | 1997-5-5 | lld:pubmed |
| pubmed-article:9022982 | pubmed:abstractText | Some thio- and the benzoyl-derivatives of deoxamuscarine were synthesized and tested as muscarinic agonists using radioligand binding assays and functional tests. In comparison with deoxamuscarine, used as reference compound, no dimension/distance modification is tolerated for correct lipophilic pocket recognition. The substitution of the ammonium group with a sulphonium group significantly decreased muscarinic potency. The so-called 'muscarinic sub-site' accepts relatively bulky functions as long as it is bound to the cyclopentane carrier by an oxygen bridge. Esterification of this moiety increases the M2 subtype selectivity, while etherification heightens that of M3. | lld:pubmed |
| pubmed-article:9022982 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9022982 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022982 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9022982 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9022982 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:9022982 | pubmed:author | pubmed-author:AmentaFF | lld:pubmed |
| pubmed-article:9022982 | pubmed:author | pubmed-author:SabbatiniMM | lld:pubmed |
| pubmed-article:9022982 | pubmed:author | pubmed-author:GiannellaMM | lld:pubmed |
| pubmed-article:9022982 | pubmed:author | pubmed-author:PiginiMM | lld:pubmed |
| pubmed-article:9022982 | pubmed:author | pubmed-author:QuagliaWW | lld:pubmed |
| pubmed-article:9022982 | pubmed:author | pubmed-author:PiergentiliAA | lld:pubmed |
| pubmed-article:9022982 | pubmed:author | pubmed-author:TayebatiS KSK | lld:pubmed |
| pubmed-article:9022982 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9022982 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:9022982 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9022982 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9022982 | pubmed:pagination | 2193-9 | lld:pubmed |
| pubmed-article:9022982 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
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| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
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| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:meshHeading | pubmed-meshheading:9022982-... | lld:pubmed |
| pubmed-article:9022982 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9022982 | pubmed:articleTitle | Muscarinic thioligands with cyclopentane nucleus. | lld:pubmed |
| pubmed-article:9022982 | pubmed:affiliation | Dipartimento di Scienze Chimiche, Università di Camerino, Italy. | lld:pubmed |
| pubmed-article:9022982 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9022982 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9022982 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
