| pubmed-article:9022529 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9022529 | lifeskim:mentions | umls-concept:C0025266 | lld:lifeskim |
| pubmed-article:9022529 | lifeskim:mentions | umls-concept:C0993630 | lld:lifeskim |
| pubmed-article:9022529 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:9022529 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:9022529 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9022529 | lifeskim:mentions | umls-concept:C1515075 | lld:lifeskim |
| pubmed-article:9022529 | lifeskim:mentions | umls-concept:C0443602 | lld:lifeskim |
| pubmed-article:9022529 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9022529 | pubmed:dateCreated | 1997-3-11 | lld:pubmed |
| pubmed-article:9022529 | pubmed:abstractText | This study examined the effects of garlic and fish-oil supplementation (alone and in combination) on fasting serum lipids and lipoproteins in hypercholesterolemic subjects. After an initial run-in phase, 50 male subjects with moderate hypercholesterolemia were randomly assigned for 12 wk to one of four groups: 1) 900 mg garlic placebo/d + 12 g oil placebo/d; 2) 900 mg garlic/d + 12 g oil placebo/d; 3) 900 mg garlic placebo/d + 12 g fish oil/d, providing 3.6 g n-3 fatty acids/d; and 4) 900 mg garlic/d + 12 g fish oil/d. In the placebo group, mean serum total cholesterol, low-density-lipoprotein cholesterol (LDL-C), and triacylglycerols were not significantly changed in relation to baseline. Mean group total cholesterol concentrations were significantly lower with garlic+fish oil (-12.2%) and with garlic (-11.5%) after 12 wk but not with fish oil alone. Mean LDL-C concentrations were reduced with garlic+fish oil (-9.5%) and with garlic (-14.2%) but were raised with fish oil (+8.5%). Mean triacylglycerol concentrations were reduced with garlic+fish oil (-34.3%) and fish oil alone (-37.3%). The garlic groups (with and without fish oil) had significantly lower ratios of total cholesterol to high-density-lipoprotein cholesterol (HDL-C) and LDL-C to HDL-C. In summary, garlic supplementation significantly decreased both total cholesterol and LDL-C whereas fish-oil supplementation significantly decreased triacylglycerol concentrations and increased LDL-C concentrations in hypercholesterolemic men. The combination of garlic and fish oil reversed the moderate fish-oil-induced rise in LDL-C. Coadministration of garlic with fish oil was well-tolerated and had a beneficial effect on serum lipid and lipoprotein concentrations by providing a combined lowering of total cholesterol, LDL-C, and triacylglycerol concentrations as well as the ratios of total cholesterol to HDL-C and LDL-C to HDL-C. | lld:pubmed |
| pubmed-article:9022529 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022529 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9022529 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022529 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9022529 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9022529 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9022529 | pubmed:issn | 0002-9165 | lld:pubmed |
| pubmed-article:9022529 | pubmed:author | pubmed-author:AdlerA JAJ | lld:pubmed |
| pubmed-article:9022529 | pubmed:author | pubmed-author:HolubB JBJ | lld:pubmed |
| pubmed-article:9022529 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9022529 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:9022529 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9022529 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9022529 | pubmed:pagination | 445-50 | lld:pubmed |
| pubmed-article:9022529 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9022529 | pubmed:meshHeading | pubmed-meshheading:9022529-... | lld:pubmed |
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| pubmed-article:9022529 | pubmed:meshHeading | pubmed-meshheading:9022529-... | lld:pubmed |
| pubmed-article:9022529 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9022529 | pubmed:articleTitle | Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. | lld:pubmed |
| pubmed-article:9022529 | pubmed:affiliation | Department of Human Biology, University of Guelph, Canada. | lld:pubmed |
| pubmed-article:9022529 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9022529 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9022529 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:9022529 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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