| pubmed-article:9018118 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C0225340 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C0699885 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C0083132 | lld:lifeskim |
| pubmed-article:9018118 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9018118 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9018118 | pubmed:dateCreated | 1997-2-27 | lld:pubmed |
| pubmed-article:9018118 | pubmed:abstractText | Growth factors and growth factor receptors are involved in tumor progression. The fibroblast growth factor receptor 2 gene encodes distinct isoforms. The isoforms which bind KGF (keratinocyte growth factor or FGF-7) are called KGF-R or FGFR2b. KGF-R is expressed in different epithelia and is involved in the control of epithelial-mesenchymal interactions. Expression of KGF-R mRNA was examined in normal human bladder and transitional cell carcinoma of the bladder (TCC) by semi-quantitative RT-PCR using TFIID and GAPDH as internal standards. In normal bladder, the KGF-R mRNA was detected in the urothelium but not in the underlying stroma. In TCCs, the level of KGF-R mRNA was generally either normal or low. Eighteen out of 54 TCCs had a KGF-R mRNA level below 30% of that found in normal urothelium. This decrease in KGF-R mRNA was not accompanied by an increase in BEK (FGFR2c) mRNA, the other major splice variant of the fibroblast growth factor receptor 2 gene. Expression of the KGF-R was also monitored by immunohistochemistry using a functional KGF-immunoglobulin chimera. The receptor was uniformly expressed throughout the normal urothelium except for the umbrella cells. Immunoreactivity for KGF-R was found to be negative in tumors with low levels of KGF-R mRNA, while the peritumoral normal urothelium was positive. Among patients with muscle invasive tumors, those exhibiting a low level of KGF-R mRNA had a significantly higher proportion of cancer deaths. Our results suggest that decreased expression of KGF-R can be considered as a marker of tumor progression in muscle invasive TCCs. | lld:pubmed |
| pubmed-article:9018118 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9018118 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9018118 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9018118 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9018118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9018118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9018118 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9018118 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9018118 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:AaronsonS ASA | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:ThieryJ PJP | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:ChopinDD | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:AbbouCC | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:DelouvéeAA | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:HoznekAA | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:LaRochelleW... | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:RadvanyiFF | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:Diez de... | lld:pubmed |
| pubmed-article:9018118 | pubmed:author | pubmed-author:El MarjouAA | lld:pubmed |
| pubmed-article:9018118 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9018118 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:9018118 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:9018118 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9018118 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9018118 | pubmed:pagination | 323-30 | lld:pubmed |
| pubmed-article:9018118 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9018118 | pubmed:meshHeading | pubmed-meshheading:9018118-... | lld:pubmed |
| pubmed-article:9018118 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9018118 | pubmed:articleTitle | Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas. | lld:pubmed |
| pubmed-article:9018118 | pubmed:affiliation | UMR 144, CNRS/Institut Curie, Paris, France. | lld:pubmed |
| pubmed-article:9018118 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9018118 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9018118 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2263 | entrezgene:pubmed | pubmed-article:9018118 | lld:entrezgene |
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