Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9014851rdf:typepubmed:Citationlld:pubmed
pubmed-article:9014851lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0037663lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0038585lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C1762617lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0021467lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0030685lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0021469lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0231491lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0680255lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0391871lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C1283071lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C1963578lld:lifeskim
pubmed-article:9014851lifeskim:mentionsumls-concept:C0525996lld:lifeskim
pubmed-article:9014851pubmed:issue1lld:pubmed
pubmed-article:9014851pubmed:dateCreated1997-2-20lld:pubmed
pubmed-article:9014851pubmed:abstractTextH2N,D-Arg,Pro,Lys,Pro,D-Phe,Gln,D-Trp,Phe,D-Trp,Leu, Leu,NH2 (L-756,867), a weak substance P antagonist, inhibited L-692,429-stimulated GH release from rat primary pituitary cells in a dose-dependent manner. At a concentration of 50 nM, L-756,867 shifted the dose-response curve of L-692,429-induced GH release to the right by about tenfold. It also impaired the ability of L-692,429 to potentiate the effect of growth hormone-releasing factor (GRF) on GH release. Substance P (1 microM) had no effect on basal or L-692,429-stimulated GH release. When tested in anesthetized rats, L-756,867 inhibited L-692,429- and growth hormone-releasing hexapeptide- (GHRP-6)-stimulated GH secretion in a dose-dependent manner. Complete inhibition was observed at an i.v. dose of 100 micrograms/kg of L-756,867. However, at the same concentration, it had no effect on GRF-induced GH secretion D-Lys3-GHRP-6, a GHRP-6 antagonist, had no effect on GHRP-6 or L-692,429-induced GH secretion even at an i.v. dose of 2 mg/kg. These results indicate that L-692,429 and GHRP-6 stimulate GH release both in vitro and in vivo via a common receptor and signaling pathway which is different from that of substance P in spite of the fact that their effects are inhibited by a weak substance P antagonist.lld:pubmed
pubmed-article:9014851pubmed:languageenglld:pubmed
pubmed-article:9014851pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:citationSubsetIMlld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9014851pubmed:statusMEDLINElld:pubmed
pubmed-article:9014851pubmed:monthJanlld:pubmed
pubmed-article:9014851pubmed:issn0022-0795lld:pubmed
pubmed-article:9014851pubmed:authorpubmed-author:SmithR GRGlld:pubmed
pubmed-article:9014851pubmed:authorpubmed-author:ChanW WWWlld:pubmed
pubmed-article:9014851pubmed:authorpubmed-author:ChengKKlld:pubmed
pubmed-article:9014851pubmed:authorpubmed-author:ButlerBBlld:pubmed
pubmed-article:9014851pubmed:authorpubmed-author:WegNNlld:pubmed
pubmed-article:9014851pubmed:authorpubmed-author:ChaungL YLYlld:pubmed
pubmed-article:9014851pubmed:issnTypePrintlld:pubmed
pubmed-article:9014851pubmed:volume152lld:pubmed
pubmed-article:9014851pubmed:ownerNLMlld:pubmed
pubmed-article:9014851pubmed:authorsCompleteYlld:pubmed
pubmed-article:9014851pubmed:pagination155-8lld:pubmed
pubmed-article:9014851pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:meshHeadingpubmed-meshheading:9014851-...lld:pubmed
pubmed-article:9014851pubmed:year1997lld:pubmed
pubmed-article:9014851pubmed:articleTitleInhibition of L-692,429-stimulated rat growth hormone release by a weak substance P antagonist: L-756,867.lld:pubmed
pubmed-article:9014851pubmed:affiliationDepartment of Growth Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA.lld:pubmed
pubmed-article:9014851pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9014851lld:pubmed