| pubmed-article:9010500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0039097 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0020858 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C2754947 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:9010500 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9010500 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9010500 | pubmed:dateCreated | 1997-2-21 | lld:pubmed |
| pubmed-article:9010500 | pubmed:abstractText | Rheumatoid arthritis synovial fluid (RA-SF) contains a distinct biological activity that selectively induces IgG2b production in LPS-activated murine B blasts. This IgG2b inducing factor (IgG2bIF) acts directly on purified LPS-activated B blasts from normal and Bruton's tyrosine kinase-defective CBA/N mice. In order to test the possibility that TGF-beta and IgG2bIF in RA-SF act in concert to induce IgG2b production, anti-TGF-beta monoclonal antibodies and RA-SF were added to LPS-activated CBA B blasts, which led to a marked reduction of IgG2b-producing cells. This result indicates that TGF-beta and IgG2bIF in RA-SF synergize in the induction of IgG2b production. TGF-beta antibodies do not inhibit IgG2b production in CBA/N B blasts, further substantiating our earlier notion that CBA/N B blasts have a higher endogenous production of TGF-beta after LPS stimulation, which might be responsible for the aberrant reactivity in btk deficient CBA/N mice. RA-SF is able to reconstitute the deficient IgG1 response in LPS- and IL-4-stimulated CBA/N B blasts. Addition of antibodies against TGF-beta had only a marginal effect on the IgG1 response, indicating that the reconstitution is mediated by another factor(s), which is present in RA-SF. | lld:pubmed |
| pubmed-article:9010500 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9010500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9010500 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9010500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9010500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9010500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9010500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9010500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9010500 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9010500 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:9010500 | pubmed:author | pubmed-author:MöllerEE | lld:pubmed |
| pubmed-article:9010500 | pubmed:author | pubmed-author:RidderstadAA | lld:pubmed |
| pubmed-article:9010500 | pubmed:author | pubmed-author:LettesjöHH | lld:pubmed |
| pubmed-article:9010500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9010500 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:9010500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9010500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9010500 | pubmed:pagination | 50-4 | lld:pubmed |
| pubmed-article:9010500 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:meshHeading | pubmed-meshheading:9010500-... | lld:pubmed |
| pubmed-article:9010500 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9010500 | pubmed:articleTitle | IgG2b inducing factor from rheumatoid arthritis synovial fluid synergizes with transforming growth factor-beta in promoting IgG2b antibody production in mouse B lymphocytes. | lld:pubmed |
| pubmed-article:9010500 | pubmed:affiliation | Department of Immunology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden. | lld:pubmed |
| pubmed-article:9010500 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9010500 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
