| pubmed-article:9003782 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C1427812 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0205410 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0205275 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C1334346 | lld:lifeskim |
| pubmed-article:9003782 | lifeskim:mentions | umls-concept:C0721534 | lld:lifeskim |
| pubmed-article:9003782 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:9003782 | pubmed:dateCreated | 1997-2-13 | lld:pubmed |
| pubmed-article:9003782 | pubmed:abstractText | Epstein-Barr virus (EBV) infects human primary B lymphocytes and induces and maintains proliferation of these cells efficiently in vitro. Mutants of Epstein-Barr virus which express EBV nuclear antigen 2 (EBNA2) in a conditional fashion allow dissection of individual contributions of viral genes to B cell immortalization. EBNA2 is a transcriptional activator of cellular and viral genes, including the viral latent membrane protein 1 (LMP1), which is essential for B cell immortalization and has oncogenic effects in non-lymphoid cells. To analyze the role of this gene in B cell immortalization, LMP1 was constitutively expressed in B cells infected with EBV carrying a conditional EBNA2 allele. In the absence of functional EBNA2, LMP1 was incapable of sustaining B cell proliferation in two independent assays but induced a phenotype consistent with prolonged cell viability. Activation of CD40 displayed a comparable phenotype. These data indicate that both CD40 activation and LMP1 expression may use a common pathway for B cell activation. Proliferation of human B cells, however, requires one or more additional signals triggered by EBNA2. | lld:pubmed |
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| pubmed-article:9003782 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9003782 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9003782 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9003782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9003782 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9003782 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9003782 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:ZeidlerRR | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:BornkammG WGW | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:BanchereauJJ | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:Van KootenCC | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:KempkesBB | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:Zimber-Strobl... | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:Hammerschmidt... | lld:pubmed |
| pubmed-article:9003782 | pubmed:author | pubmed-author:MarschallGG | lld:pubmed |
| pubmed-article:9003782 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9003782 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:9003782 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:9003782 | pubmed:owner | NLM | lld:pubmed |
